The Holistic Effects of Acupuncture Treatment

Table 1

Summary of experimental studies of acupuncture articles on genomic technologies.

Author/year	Treatment manner	Disease	Acupoint	Testing technique	Upregulation gene	Downregulation gene
Li et al./2012 [32]	Electroacupuncture	Hypercholesterolemia	ST40 (Fenglong)	cDNA microarray	NM_013474, NM_008138, NM_008712, and so forth; (18 genes)	NM_133668, NM_007409, NM_011407, and so forth; (13 genes)
Choi et al./2011 [33]	Acupuncture	Parkinson’s disease	GB34 (Yanglingquan); LR3 (Taichong)	cDNA microarray	Atp2a1, Dub2a, Klhl31, and Tnnt3.	Hba-a1, Hba-a2, Hbb-b1, EG383229, Ppbp, and Ube2l6
Shiue et al./2010 [34]	Acupuncture	Allergic rhinitis	LI4 (Hegu); ST36 (Zusanli); LI20 (Yingxiang); EX-HN3 (Yintang)	Microarray	the most upregulated genes; in Ph (−) patient	The most downregulated genes in Ph (+) patients
Tan et al./2010 [35]	Warm needling	Knee osteoarthritis	RN4 (Guanyuan); RN6 (Qihai); ST36; EX32 (Xiyan); GB34	cDNA microarray	14, 45, 11, and 31 genes	16, 56, 20, and 10 genes
Sohn et al./2010 [36]	Electroacupuncture	Immunomodulation	ST36	Microarray	Sod1, IL1f9, Oprl1, and Oprk1	Cyp2a4, ITGA4, and Foxf2
Wang et al./; 2009 [37]	Electroacupuncture	Spinal cord injury (SCI)	ST36; GB39 (Xuanzhong); ST32 (Futu); SP6 (Sanyinjiao)	Microarray	CNDF, FGF-13, FGF-1, IGF-1R, CGRP-α, and NPY	CNDF (1dpo), CNDF (14dpo), FGF4, IGF1 (14dpo),; TGFβ2, and PF75
Shiue et al./; 2008 [38]	Acupuncture	Allergic rhinitis	LI4; ST36; LI20; EX-HN3	cDNA microarray	9 genes	72 genes
Gao et al./2007 [29]	Electroacupuncture	Pain	ST36	Oligonucleotide; microarray	NM_021669, NM_013099,; NM_057207, NM_053868,; NM_131912, AF255612,; NM_078620	N.A.
Li and Zhang/; 2007 [39]	Electroacupuncture	Hypercholesterolemia	ST40	Oligo microarray	Gdf15, Ppap, and OATP-1	Slpi, LXR
Ding et al./2006 [40]	Acupuncture	Aging	CV17 (Shanzhong); CV12 (Zhongwan); CV6 (Qihai); ST36; SP10 (Xuehai)	cDNA; microarray	Hsp84, Hsp86, and YB-1	N.A.
Kim et al./2005 [41]	Electroacupuncture	Natural killer cell activities	ST36	Oligo; microarray	PTK, VCAM-1	PTP, SHP-1
Guo et al./2004 [42]	Electroacupuncture	Ischemia	GV26 (Renzhong); GV20 (Baihui)	cDNA; microarray	27 genes	2 genes
Ko et al./2002 [43]	Electroacupuncture	Neuropathic pain	ST36	cDNA; microarray	Opioid receptor, MAP kinase, zinc finger protein, and; tyrosine phosphatase related genes	N.A.