Safety Evaluation of Oral Toxicity of Carica papaya Linn. Leaves: A Subchronic Toxicity Study in Sprague Dawley Rats
Table 1
Hematological values of control group and rats treated with C. papaya leaf extract measured during the subchronic toxicity study.
Male rats
Control
0.01 g/kg BW
0.14 g/kg BW
2 g/kg BW
WBC (10³/L)
4.74 ± 2.04
6.01 ± 2.84
3.69 ± 1.55
6.24 ± 2.73
RBC (106 L)
7.89 ± 0.42
7.96 ± 0.40
7.88 ± 0.51
8.03 ± 0.37
HGB (g/dL)
16.30 ± 0.49
16.13 ± 0.72
16.27 ± 0.81
16.34 ± 0.73
HCT (%)
40.08 ± 1.42
39.83 ± 1.97
40.11 ± 1.87
39.97 ± 1.86
MCV (fL)
50.84 ± 1.69
49.98 ± 1.32
50.94 ± 1.74
49.79 ± 1.55
MCH (pg)
20.69 ± 0.74
20.24 ± 0.53
20.67 ± 0.54
20.38 ± 0.56
MCHC (g/dL)
40.70 ± 0.50
40.51 ± 0.42
40.58 ± 0.49
40.93 ± 0.50
PLT (10³/L)
637.67 ± 100.04
697.88 ± 69.91
563.44 ± 209.03
718.67 ± 111.74
Female rats
Control
0.01 g/kg BW
0.14 g/kg BW
2 g/kg BW
WBC (10³/L)
2.13 ± 0.98
1.71 ± 0.97
1.65 ± 1.25
3.40 ± 2.41
RBC (106 L)
7.22 ± 0.45
7.05 ± 0.21
6.89 ± 0.51
6.85 ± 0.68
HGB (g/dL)
15.57 ± 0.79
15.16 ± 0.38
14.61 ± 1.09
14.38 ± 1.29
HCT (%)
37.57 ± 1.97
36.55 ± 0.98
35.45 ± 2.83
34.70 ± 3.29
MCV (fL)
52.08 ± 1.59
51.87 ± 0.97
51.45 ± 1.04
50.70 ± 1.81
MCH (pg)
21.59 ± 0.72
21.52 ± 0.46
21.23 ± 0.42
21.04 ± 0.67
MCHC (g/dL)
41.47 ± 0.62
41.49 ± 0.48
41.29 ± 0.60
41.54 ± 0.45
PLT (10³/L)
708.40 ± 117.74
681.70 ± 56.09
464.50 ± 272.37
535.00 ± 290.60
Values are expressed as mean ± standard deviation (/group). WBC: white blood cells, RBC: red blood cells, HGB: Hemoglobin, HCT: hematocrit, MCV: mean corpuscular volume, MCH: mean cell hemoglobin, MCHC: mean corpuscular hemoglobin concentration, and PLT: platelet. value less than 0.05 (), significant value.
