Research Article
Preliminary Study on Pain Reduction of Monosodium Iodoacetate-Induced Knee Osteoarthritis in Rats by Carbon Dioxide Laser Moxibustion
Figure 2
Relative expression levels of cytokine in left dorsal horn tissues measured from the (a) CO2 laser moxibustion group and (b) sham treatment group 28 d after induction of knee osteoarthritis (results of microarray analyses; upward bars indicate upregulation versus blank control; downward bars indicate downregulation; MIA + LM: CO2 laser moxibustion group; MIA + sham LM: sham treatment group; Normal: blank control group;, , and). Values are the mean and SD. Beta-NGF: beta-nerve growth factor; CINC-1/2 alpha/3: cytokine-induced neutrophil chemoattractant-1/2 alpha/3; GM-CSF: granulocyte-macrophage colony-stimulating factor; ICAM-1: intercellular adhesion molecule 1; IL-1 alpha/1 beta/1 R6/2/4/6/10/13: interleukin-1 alpha/1 beta/1 R6/2/4/6/10/13; LIX: lipopolysaccharide induced CXC chemokine; MCP-1: monocyte chemotactic protein-1; MIP-3 alpha: macrophage inflammatory protein-3 alpha; MMP-8: metalloproteinases 8; PDGF-AA: platelet-derived growth factor-AA; RAGE: receptor for advanced glycosylation end products; TNF-alpha: tumor necrosis factors-alpha; VEGF: vascular endothelial growth factor.
