Effect of Estragole on Leukocyte Behavior and Phagocytic Activity of Macrophages
EST inhibited in vivo leukocyte migration in rats. The animals were orally treated with EST (250, 500, or 750 mg/kg) and indomethacin (5.0 mg/kg) 30 minutes before the injection of carrageenan (100 μg/scrotum). (a) Number of leukocytes rolling, (b) number of leukocytes adherent during 10-minute periods after 2 h, and (c) leukocytes migrate after 4 h of inflammatory stimulus. Values represent mean ± SEM ( animals/group) and are representative of three independent experiments. versus vehicle; versus carrageenan-injected group (one-way ANOVA, Tukey’s test).