White Pepper and Piperine Have Different Effects on Pharmacokinetics of Puerarin in Rats

Table 2

Pharmacokinetic parameters of puerarin after an intravenous administration of puerarin (40 mg/kg) to rats in the presence and absence of piperine and white pepper (𝑛=6, mean ± SD).

Parameters	Control	With piperine		With white pepper
		10 mg/kg	20 mg/kg	125 mg/kg	250 mg/kg
AUC0--𝑡 (𝜇g/mL·h)	83.665±19.132	89.287±23.868	80.638±15.667	95.826±20.052	102.026±24.22^∗
AUC0--∞ (𝜇g/mL·h)	90.221±17.419	98.366±23.219	91.982±12.127	104.132±21.774	115.27±20.435^∗
𝑉𝑑 (L/kg)	0.365±0.123	0.363±0.07	0.402±0.119	0.366±0.19	0.542±0.301
CL (L/h/kg)	0.433±0.109	0.389±0.118	0.441±0.058	0.413±0.098	0.384±0.097
𝑡1/2 (h)	0.715±0.201	0.702±0.204	0.652±0.247	0.759±0.186	0.929±0.281

Asterisks signs designate significant differences: ^∗𝑃<0.05 versus control group given puerarin only.