Evidence-Based Complementary and Alternative Medicine / 2014 / Article / Tab 1

Review Article

Pharmacopuncture for Cancer Care: A Systematic Review

Table 1

Characteristics of the included studies: pain.

AuthorSample size (M/F)
Cancer type
Intervention Control Outcome measuresResult
InterventionControl

Liu 2010 [16]50 (31/19)
Various
Bucinnazine (100 mg) injection at ST35 ( = 28)Bucinnazine (100 mg), IM
( = 22)
Responder rate (%)a85.7%*59.1%
Li 2009 [17]40 (22/18)
Various
Fentanyl plaster (4.2 mg) and Bucinnazine injection at ST36
( = 20)
q8h
Fentanyl plaster (4.2 mg) and Bucinnazine, IM ( = 20)
q8h
Responder rate (%)80%80%
Shen 2009 [18]52 (23/25)
Various
Stauntoniae injection at ear acupoints ( = 23)
0.1–0.3 mL at each point, qd
Oxycodon, po ( = 25)
(1) moderate pain: 5 mg, bid
(2) severe pain: 10 mg, bid (dose escalation by 25–50% if pain gets worse)
(A) Responder rate (%)
(B) Onset of analgesia, duration of analgesia (min, mean ± SD)
(A) 91.3%
(B) 17.7 ± 6.9**,
18.2 ± 1.3**
(A) 92%
(B) 31.4 ± 6.6,
11.8 ± 1.0
Dou et al. 2004 [19]120 (67/43)
Late gastric cancer
Pethidine (50–100 mg) injection at ST36 ( = 43) (1) MA at ST36 ( = 39)
(2) Pethidine (50–100 mg), IM
( = 39)
Responder rate (%)93%**(1) 71.8%
(2) 60.5%
Wang et al. 2004a [20] 102 (35/67)
Various
Anisodamine (10 mg), dexamethasone (5 mg), and energy synbiotics injection (4 mL) at bilateral ST36, and Vit. B12 (500  g) at bilateral SP10
( = 52)
qd
Pethidine (100 mg), IM ( = 50)
qd
Responder rate (%)b0 h: 57.7%** 
0.5–4 h: 80.8% 
4–24 h: 75%** 
24–72 h: 78.9%** 
96 h: 80.8%**
0 h: 0% 
0.5–4 h: 88% 
4–24 h: 50%
24–72 h: 50%
96 h: 52%
Wang et al. 2004b [21]120 (61/59)
Various
Anisodamine (10 mg), dexamethasone (5 mg), and energy synbiotics injection (4 mL) at bilateral ST36, and Vit. B12 (500  g) at bilateral SP10
( = 60)
qd
Pethidine (100 mg), IM ( = 60)
qd
Responder rate (%)b0 h: 51.7%** 
4 h: 93.3% 
24 h: 81.7%** 
72 h: 85%** 
96 h: 91.7%**
0 h: 0%
4 h: 95%
24 h: 15%
72 h: 60%
96 h: 63.3%
Bai 2003 [22]120 (71/49)
Various
Nefopam injection (20 mg) at bilateral ST36 ( = 60)Pethidine (50 mg), IM ( = 60)Responder rate (%)81.6%*65%
Guan et al. 2001 [23]122 (86/36)
Various
Distilled and purified Chinese herbs (4 mL) injection at various acupoints ( = 61)
qd (bid, if pain is severe)
Western medicine (4 mL) injection at various acupoints
( = 61)
qd (bid, if pain is severe)
Responder rate (%)b57.4%*42.6%

AE: adverse events; bid: twice a day; h: hour(s); IM: intramuscular injection; MA: manual acupuncture; min: minute(s); NR: not reported; po: orally; q8h: every 8 hours; qd: everyday; SD: standard deviation; Vit.: vitamin.
Acupuncture point ST36 refers to 36th point of stomach meridian and extra points have different nomenclature (e.g., Ex-UE7 means 7th extra point in the upper extremity).
Responder rate: (number of participants with any improvement from the intervention/total number of participants) * 100(%) unless stated otherwise.
aResponder rate: (number of participants with no need of analgesia/total number of participants) * 100(%).
bResponder rate: (number of participants with improvement from the intervention with no sleep disturbance/total number of participants) * 100(%).
* ; ** .