Deciphering Molecular Mechanism Underlying Hypolipidemic Activity of Echinocystic Acid
Figure 3
Molecular docking of echinocystic acid (EA) with DGAT in 3D diagram. (a) Three-dimensional structure of DGAT. (b) Optimized docking conformation of EA in the hydrophobic pocket of DGAT. The surface of DGAT was color-coded by electrostatic potential. Red, positive charge; white, neutral; blue, negative charge. (c) Detailed binding mode of EA with DGAT. Dotted blue line displays the hydrogen bonding between the carboxyl group of EA and residue Lys 193 of DGAT.
