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Evidence-Based Complementary and Alternative Medicine
Volume 2014, Article ID 826380, 8 pages
http://dx.doi.org/10.1155/2014/826380
Research Article

Nigella sativa Fixed and Essential Oil Supplementation Modulates Hyperglycemia and Allied Complications in Streptozotocin-Induced Diabetes Mellitus

1Faculty of Food Science and Technology, University of Putra Malaysia (UPM), Malaysia
2National Institute of Food Science & Technology, University of Agriculture, Faisalabad, Pakistan
3The Patent Office, Karachi, Pakistan
4Department of Agronomy, Bahauddin Zakariya University, Multan 60800, Pakistan
5Department of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, Fisciano, 84084 Salerno, Italy

Received 16 June 2013; Accepted 3 December 2013; Published 8 January 2014

Academic Editor: Mohamed Eddouks

Copyright © 2014 Muhammad Tauseef Sultan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In the recent era, diabetes mellitus has emerged as one of the significant threats to public health and this situation demands the attention of the researchers and allied stakeholders. Dietary regimens using functional and nutraceutical foods are gaining wide range of acceptance and some traditional medicinal plants are of considerable importance. The main objective of this instant study was to explore the antidiabetic potential of Nigella sativa fixed oil (NSFO) and essential oil (NSEO). Three experimental groups of rats received diets during the entire study duration, that is, D1 (control), D2 (NSFO: 4.0%), and D3 (NSEO: 0.30%). Experimental diets (NSFO & NSEO) modulated the lipid profile, while decreasing the antioxidant damage. However, production of free radicals, that is, MDA, and conjugated dienes increased by 59.00 and 33.63%, respectively, in control. On the contrary, NSFO and NSEO reduced the MDA levels by 11.54 and 26.86% and the conjugated dienes levels by 32.53 and 38.39%, respectively. N. sativa oils improved the health and showed some promising anti-diabetic results.