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Evidence-Based Complementary and Alternative Medicine
Volume 2014, Article ID 832824, 9 pages
Research Article

Clinical Data Mining Related to the Japanese Kampo Concept “Hie” (Oversensitivity to Coldness) in Men and Pre- and Postmenopausal Women

1Center for Kampo Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
2Faculty of Environment and Information Study, Keio University, 532 Endo, Fujisawa, Kanagawa 252-0882, Japan
3Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan

Received 19 July 2013; Revised 5 December 2013; Accepted 29 December 2013; Published 24 February 2014

Academic Editor: Heidrun Reissenweber-Hewel

Copyright © 2014 H. Tokunaga et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Hie” is a subjective oversensitivity to cold and a condition experienced in 60% of Japanese citizens. The condition of hie has not been documented in Western medicine. However, in Kampo medicine, hie is an important target of treatment, because it has been considered one of the sources of all kinds of diseases. This study aimed to clarify the symptoms and findings associated with hie and contribute to increased precision in hie diagnosis. During 2005-2006, data from interviews of 1691 patients during their initial visit to the Kampo Clinic of Keio University Hospital were analyzed using a classification and regression tree (CART) analysis, a data mining technique. Symptoms and findings characteristic of each group are follows as, postmenopausal women: fatigability, absence of lower abdominal pain, and absence of hot flashes of feet: women with menstruation: leg swelling, knee pain, and abdominal pain; men: insomnia, leg weakness, and absence of excess saliva. From the perspective of Kampo medicine the result suggested that the feature of hie condition in postmenopausal women, women with menstruation, and men is statistically different.