Pharmacokinetics of Two Alkaloids after Oral Administration of Rhizoma Coptidis Extract in Normal Rats and Irritable Bowel Syndrome Rats

Table 2

Pharmacokinetic parameters of berberine and palmatine in rat after oral administration of Rhizoma Coptidis extract at a dose of 96 mg/kg (mean SD, ).

Parameters	Berberine		Palmatine
	Control	Model	Control	Model
(min)	945.8 ± 349.5	836.2 ± 253.3	1611.7 ± 616.0	1521.7 ± 710.9
(min)	15.0 ± 0.0	15.0 ± 0.0	15.0 ± 0.0	15.0 ± 0.0
(ng/mL)	20.0 ± 12.1	39.2 ± 7.9**	8.1 ± 2.2	9.1 ± 1.2
(min·ng/mL)	4954.3 ± 784.3	9874.7 ± 2713.1**	1470.6 ± 229.8	2186.6 ± 693.4*
/ (L/kg)	5124.3 ± 1841.2	2503.9 ± 542.4**	4869.6 ± 1237.6	4315.9 ± 1111.3
CL/F (L/h/kg)	198.6 ± 75.4	124.3 ± 27.4*	147.4 ± 45.3	119.3 ± 28.1

and * compared with the control group.