Wen-Dan Decoction Improves Negative Emotions in Sleep-Deprived Rats by Regulating Orexin-A and Leptin Expression
Table 5
The effect of sleep deprivation on mRNA expression of orexin-A, OX1R, and Ob-R in prefrontal cortex and hypothalamus and the regulation of WDD.
Part
Group
Orexin-A
OX1R
OB-R
Prefrontal cortex
Control group
1.62 ± 0.54
0.80 ± 0.34
1.10 ± 0.10
Model group
0.70 ± 0.20
0.34 ± 0.14
0.61 ± 0.13**
Diazepam group
1.65 ± 0.22▲▲
0.64 ± 0.11▲
1.91 ± 0.07**▲▲
Wen-dan group
2.15 ± 0.04▲▲★
0.79 ± 0.10▲
0.79 ± 0.07*★★
Hypothalamus
Control group
2.41 ± 1.41
0.82 ± 0.23
1.28 ± 0.45
Model group
1.91 ± 1.01
0.99 ± 0.04
2.55 ± 0.23**
Diazepam group
1.22 ± 0.34
0.78 ± 0.26
2.71 ± 0.24**▲
Wen-dan group
2.09 ± 0.17
1.65 ± 0.74
4.30 ± 0.76*▲★
: versus the control group; : versus the control group; ▲: versus the model group; ▲▲: versus the model group; ★: versus the diazepam group; and ★★: versus the diazepam group. Data are presented as mean ± standard error of the mean (SEM).
