Electroacupuncture Promotes Proliferation of Amplifying Neural Progenitors and Preserves Quiescent Neural Progenitors from Apoptosis to Alleviate Depressive-Like and Anxiety-Like Behaviours
EA reverses the inhibition of ANPs proliferation in the DG of the stressed rats. (a) Representative triple-stained sections in the DG: BrdU (red), GFAP (green), and Hoechst (blue). The translucent square in the Normal figure is magnified in (b) to point out the division of quiescent neural progenitors (QNPs) and amplifying neural progenitors (ANPs). The BrdU+/GFAP− cells (black arrows) are considered the proliferating ANPs and those BrdU+/GFAP+ cells (white arrows) the proliferating QNPs. Scale bar represents 100 μm. Bar gram in panel (c) depicts (mean ± SE) the quantification of the dividing cells belonging to different subtypes of NPs in the whole DG. The proliferations of QNPs and ANPs are both decreased by CUS, and EA upregulates the ANP proliferation in stressed rats. and *, versus Normal group; #, versus Model group.
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