Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2014, Article ID 945814, 11 pages
http://dx.doi.org/10.1155/2014/945814
Research Article

Proteomic Identification of Nrf2-Mediated Phase II Enzymes Critical for Protection of Tao Hong Si Wu Decoction against Oxygen Glucose Deprivation Injury in PC12 Cells

1College of Pharmaceutical Sciences, Southwest University, 2 Tiansheng Road, Beibei District, Chongqing 400716, China
2College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 611137, China
3Institute of Laboratory Animals, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu, Sichuan 610212, China

Received 9 February 2014; Revised 27 March 2014; Accepted 7 April 2014; Published 11 May 2014

Academic Editor: Shao Li

Copyright © 2014 Hong-yi Qi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. T. Efferth, P. C. H. Li, V. S. B. Konkimalla, and B. Kaina, “From traditional Chinese medicine to rational cancer therapy,” Trends in Molecular Medicine, vol. 13, no. 8, pp. 353–361, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. M. Youns, J. D. Hoheisel, and T. Efferth, “Traditional Chinese Medicines (TCMs) for molecular targeted therapies of tumours,” Current Drug Discovery Technologies, vol. 7, no. 1, pp. 37–45, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. X. Liu and D.-A. Guo, “Application of proteomics in the mechanistic study of traditional Chinese medicine,” Biochemical Society Transactions, vol. 39, no. 5, pp. 1348–1352, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. W. C.-S. Cho, “Application of proteomics in Chinese medicine research,” American Journal of Chinese Medicine, vol. 35, no. 6, pp. 911–922, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. L. Wang, G.-B. Zhou, P. Liu et al., “Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia,” Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 12, pp. 4826–4831, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. L. L. L. Yeh, J.-Y. Liu, K.-S. Lin et al., “A randomised placebo-controlled trial of a traditional Chinese herbal formula in the treatment of primary dysmenorrhoea,” PloS ONE, vol. 2, no. 8, p. e719, 2007. View at Google Scholar · View at Scopus
  7. S. M. Wang, X. Y. Xu, W. L. Zhang, Y. Y. Hu, and W. H. Chen, “Effects of Taohongsiwu Decoction and its separated prescriptions decoction on angiogenesis of chick chorioallantoic membrane,” Zhongguo Zhong Yao Za Zhi, vol. 27, no. 4, pp. 4–7, 2005. View at Google Scholar
  8. C. J. Wu, J. T. Chen, T. L. Yen et al., “Neuroprotection by the traditional Chinese medicine, Tao-Hong-Si-Wu-Tang, against middle cerebral artery occlusion-induced cerebral ischemia in rats,” Evidence-based Complementary and Alternative Medicine, vol. 2011, Article ID 803015, 9 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Ishiyama, Y. Miyazono, K. Sasamoto, Y. Ohkura, and K. Ueno, “A highly water-soluble disulfonated tetrazolium salt as a chromogenic indicator for NADH as well as cell viability,” Talanta, vol. 44, no. 7, pp. 1299–1305, 1997. View at Publisher · View at Google Scholar · View at Scopus
  10. H. Qi, Y. Han, and J. Rong, “Potential roles of PI3K/Akt and Nrf2-Keap1 pathways in regulating hormesis of Z-ligustilide in PC12 cells against oxygen and glucose deprivation,” Neuropharmacology, vol. 62, no. 4, pp. 1659–1670, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. A. Shevchenko, H. Tomas, J. Havliš, J. V. Olsen, and M. Mann, “In-gel digestion for mass spectrometric characterization of proteins and proteomes,” Nature Protocols, vol. 1, no. 6, pp. 2856–2860, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. H. Qi, S. O. Siu, Y. Chen et al., “Senkyunolides reduce hydrogen peroxide-induced oxidative damage in human liver HepG2 cells via induction of heme oxygenase-1,” Chemico-Biological Interactions, vol. 183, no. 3, pp. 380–389, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. J. Zhao, A. N. Moore, J. B. Redell, and P. K. Dash, “Enhancing expression of Nrf2-driven genes protects the blood-brain barrier after brain injury,” Journal of Neuroscience, vol. 27, no. 38, pp. 10240–10248, 2007. View at Publisher · View at Google Scholar · View at Scopus
  14. J. A. Hillion, K. Takahashi, D. Maric, C. Ruetzler, J. L. Barker, and J. M. Hallenbeck, “Development of an ischemic tolerance model in a PC12 cell line,” Journal of Cerebral Blood Flow and Metabolism, vol. 25, no. 2, pp. 154–162, 2005. View at Publisher · View at Google Scholar · View at Scopus
  15. Y. F. Chen, “Traditional Chinese herbal medicine and cerebral ischemia,” Front Biosci, vol. 4, pp. 809–817, 2012. View at Google Scholar
  16. H. Kim, “Neuroprotective herbs for stroke therapy in traditional eastern medicine,” Neurological Research, vol. 27, no. 3, pp. 287–301, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. Y. Xu, S. M. Liachenko, P. Tang, and P. H. Chan, “Faster recovery of cerebral perfusion in SOD1-overexpressed rats after cardiac arrest and resuscitation,” Stroke, vol. 40, no. 7, pp. 2512–2518, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. P. H. Chan, H. Kamii, G. Yang et al., “Brain infarction is not reduced in SOD-1 transgenic mice after a permanent focal cerebral ischemia,” NeuroReport, vol. 5, no. 3, pp. 293–296, 1993. View at Google Scholar · View at Scopus
  19. G. Yang, P. H. Chan, J. Chen et al., “Human copper-zinc superoxide dismutase transgenic mice are highly resistant to reperfusion injury after focal cerebral ischemia,” Stroke, vol. 25, no. 1, pp. 165–170, 1994. View at Google Scholar · View at Scopus
  20. W. Liedtke, W. Edelmann, P. L. Bieri et al., “GFAP is necessary for the integrity of CNS white matter architecture and long-term maintenance of myelination,” Neuron, vol. 17, no. 4, pp. 607–615, 1996. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Bauer and I. Bauer, “Heme oxygenase-1: redox regulation and role in the hepatic response to oxidative stress,” Antioxidants and Redox Signaling, vol. 4, no. 5, pp. 749–758, 2002. View at Google Scholar · View at Scopus
  22. M. D. Maines, “The heme oxygenase system: a regulator of second messenger gases,” Annual Review of Pharmacology and Toxicology, vol. 37, pp. 517–554, 1997. View at Google Scholar · View at Scopus
  23. T. Kobayashi, Y. Watanabe, Y. Saito et al., “Mice lacking the glutamate-cysteine ligase modifier subunit are susceptible to myocardial ischaemia-reperfusion injury,” Cardiovascular Research, vol. 85, no. 4, pp. 785–795, 2010. View at Publisher · View at Google Scholar · View at Scopus
  24. D. Liu, I. Evans, G. Britton, and I. Zachary, “The zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesis,” Oncogene, vol. 27, no. 21, pp. 2989–2998, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. L. Li, J. Carter, X. Gao, J. Whitehead, and W. G. Tourtellotte, “The neuroplasticity-associated Arc gene is a direct transcriptional target of early growth response (Egr) transcription factors,” Molecular and Cellular Biology, vol. 25, no. 23, pp. 10286–10300, 2005. View at Publisher · View at Google Scholar · View at Scopus
  26. E. F. Wagner and R. Eferl, “Fos/AP-1 proteins in bone and the immune system,” Immunological Reviews, vol. 208, pp. 126–140, 2005. View at Google Scholar · View at Scopus
  27. N. Xia, A. Cheng, T. Lessor, Y. Zhang, and A. W. Hamburger, “Ebp1, an ErbB-3 binding protein, interacts with Rb and affects Rb transcriptional regulation,” Journal of Cellular Physiology, vol. 187, no. 2, pp. 209–217, 2001. View at Publisher · View at Google Scholar · View at Scopus
  28. M. Squatrito, M. Mancino, M. Donzelli, L. B. Areces, and G. F. Draetta, “EBP1 is a nucleolar growth-regulating protein that is part of pre-ribosomal ribonucleoprotein complexes,” Oncogene, vol. 23, no. 25, pp. 4454–4465, 2004. View at Publisher · View at Google Scholar · View at Scopus
  29. J. S. Truettner, K. Hu, C. L. Liu, W. D. Dietrich, and B. Hu, “Subcellular stress response and induction of molecular chaperones and folding proteins after transient global ischemia in rats,” Brain Research, vol. 1249, pp. 9–18, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. W. Paschen, C. G. Proud, and G. Mies, “Shut-down of translation, a global neuronal stress response: mechanisms and pathological relevance,” Current Pharmaceutical Design, vol. 13, no. 18, pp. 1887–1902, 2007. View at Publisher · View at Google Scholar · View at Scopus
  31. E. H. Lo, M. A. Moskowitz, and T. P. Jacobs, “Exciting, radical, suicidal: how brain cells die after stroke,” Stroke, vol. 36, no. 2, pp. 189–192, 2005. View at Publisher · View at Google Scholar · View at Scopus
  32. Y. Takagi, T. Tokime, K. Nozaki, Y. Gon, H. Kikuchi, and J. Yodoi, “Redox control of neuronal damage during brain ischemia after middle cerebral artery occlusion in the rat: immunohistochemical and hybridization studies of thioredoxin,” Journal of Cerebral Blood Flow and Metabolism, vol. 18, no. 2, pp. 206–214, 1998. View at Google Scholar · View at Scopus
  33. A. Datta, J. E. Park, X. Li et al., “Phenotyping of an in vitro model of ischemic penumbra by iTRAQ-based shotgun quantitative proteomics,” Journal of Proteome Research, vol. 9, no. 1, pp. 472–484, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. Q. Zhang, J. Pi, C. G. Woods, and M. E. Andersen, “A systems biology perspective on Nrf2-mediated antioxidant response,” Toxicology and Applied Pharmacology, vol. 244, no. 1, pp. 84–97, 2010. View at Publisher · View at Google Scholar · View at Scopus
  35. T. Nguyen, P. J. Sherratt, and C. B. Pickett, “Regulatory mechanisms controlling gene expression mediated by the antioxidant response element,” Annual Review of Pharmacology and Toxicology, vol. 43, pp. 233–260, 2003. View at Publisher · View at Google Scholar · View at Scopus
  36. S. Li, B. Zhang, and N. Zhang, “Network target for screening synergistic drug combinations with application to traditional Chinese medicine,” BMC Systems Biology, vol. 5, no. 1, article S10, 2011. View at Publisher · View at Google Scholar · View at Scopus
  37. C. L. Saw, A. Y. Yang, D. C. Cheng et al., “Pharmacodynamics of ginsenosides: antioxidant activities, activation of Nrf2, and potential synergistic effects of combinations,” Chemical Research in Toxicology, vol. 25, no. 8, pp. 1574–1580, 2012. View at Google Scholar
  38. S. Li, B. Zhang, D. Jiang, Y. Wei, and N. Zhang, “Herb network construction and co-module analysis for uncovering the combination rule of traditional Chinese herbal formulae,” BMC Bioinformatics, vol. 11, supplement 11, article S6, 2010. View at Publisher · View at Google Scholar · View at Scopus
  39. A. Y. Shih, P. Li, and T. H. Murphy, “A small-molecule-inducible Nrf2-mediated antioxidant response provides effective prophylaxis against cerebral ischemia in vivo,” Journal of Neuroscience, vol. 25, no. 44, pp. 10321–10335, 2005. View at Publisher · View at Google Scholar · View at Scopus
  40. R. Morishita, T. Sugimoto, M. Aoki et al., “In vivo transfection of cis element 'decoy' against nuclear factor-κB binding site prevents myocardial infarction,” Nature Medicine, vol. 3, no. 8, pp. 894–899, 1997. View at Publisher · View at Google Scholar · View at Scopus