Suxiao Jiuxin Pill Induces Potent Relaxation and Inhibition on Contraction in Human Artery and the Mechanism
Figure 2
Mean concentration- (mM) contraction (mN) curves for KCl when Suxiao Jiuxin Pill 1 mg/mL (■), 10 mg/mL (▲), or vehicle ; GTN (■), (▲), or vehicle ; and amlodipine (■), −6.6 log M (▲), or vehicle were added 30 min (except for GTN were added 10 min) before the contraction started in the human IMA ring segments ( in each group). Three rings from an IMA segment taken from the same patient were allocated into each group. Values are expressed as mean ± SEM. compared to vehicle group in 1 mg/mL Suxiao Jiuxin Pill pretreatment; , compared to vehicle group in 10 mg/mL Suxiao Jiuxin Pill pretreatment; compared to the control (vehicle) in amlodipine pretreatment (unpaired -test). between the treatment of amlodipine and the control (vehicle) in KCl-contracted groups. KCl: potassium chloride; GTN: glyceryl trinitrate; Suxiao: Suxiao Jiuxin Pill; Aml: amlodipine.
