The Effects of Maekmoondong-Tang on Cockroach Extract-Induced Allergic Asthma

Figure 8

The effect of MMDT treatment on AHR to aerosolized methacholine. Penh was measured with OCP-3000. The mice were administered MMDT (100, 200, and 400 mg/kg) and MK (10 mg/kg) as described in materials and methods. The airway responsiveness to aerosolized methacholine was measured 24 h after the last CKA challenge. Normal control mice treated with PBS only (NC), CKA-challenged mice treated with PBS (CKA), CKA-challenged mice treated with 10 mg/kg of Montelukast (MK), CKA-challenged mice treated with 100 mg/kg of MMDT (MMDT 100 mg/kg), CKA-challenged mice treated with 200 mg/kg of MMDT (MMDT 200 mg/kg), and CKA-challenged mice treated with 400 mg/kg of MMDT (MMDT 400 mg/kg). The data are shown as the mean ± S.E.M. Statistical analysis was conducted by one-way ANOVA followed by the Newman-Keuls Multiple Comparison test (significantly different from NC, *𝑃<0.05, **𝑃<0.01, ***𝑃<0.001; significantly different from CKA, ^#𝑃<0.05, ^##𝑃<0.01, ^###𝑃<0.001, 𝑛=6-7).