Identification of a Predictive Biomarker for the Beneficial Effect of Keishibukuryogan, a Kampo (Japanese Traditional) Medicine, on Patients with Climacteric Syndrome

Table 3

The patients’ hormone levels before and after treatment compared by CA repeat polymorphism of the ERβ gene.

	SS	SL	LL	𝑃
	𝑛=9	𝑛=12	𝑛=13
E2 (pg/mL)
Before	69.2±103.9	65.2±89.5	104.6±142.8	0.305
After	59.0±97.3	32.0±41.6	78.3±100.9	0.235
FSH (mIU/mL)
Before	49.0±29.0	53.4±27.2	24.1±29.3	0.044^#
After	39.1±21.7	55.1±29.5	25.5±26.7	0.051
AMH (pmol/L)
Before	1.33±1.03	1.12±1.22	6.46±7.53	0.095
After	1.11±1.22	0.90±0.48	4.42±4.83	0.107

Data are mean ± SD. S: short allele, L: long allele. 𝑃 values (SS versus SL versus LL) were obtained by Kruskal-Wallis test or 1-way ANOVA. ^#𝑃<0.05.