Identification of a Predictive Biomarker for the Beneficial Effect of Keishibukuryogan, a Kampo (Japanese Traditional) Medicine, on Patients with Climacteric Syndrome

Table 4

Comparison of Kupperman index components before and after 12 weeks’ treatment by genotypes of the CA repeat polymorphism of the ER𝛽 gene.

	SS	SL	LL	𝑃
	𝑛=9	𝑛=12	𝑛=13
Vasomotor
Before	9.78±2.11	10.67±1.97	10.46±2.03	0.583
After	9.33±2.00	10.00±2.70	7.08±4.05^∗	0.116
Paresthesia
Before	1.33±1.73	1.33±1.56	2.00±1.83	0.563
After	1.33±1.41	1.33±1.30	1.38±2.06	0.904
Insomnia
Before	3.11±1.76	2.83±2.17	2.77±2.65	0.933
After	2.44±1.67	2.33±2.23	2.15±2.38	0.884
Nervousness
Before	3.11±1.76	3.33±1.56	3.69±1.97	0.747
After	3.11±2.26	3.00±1.60	2.92±1.93	0.973
Melancholia
Before	1.78±0.97	1.92±0.90	1.69±1.18	0.916
After	1.56±0.88	1.25±0.75^∗	1.38±1.19	0.711
Vertigo
Before	0.78±0.67	1.00±0.95	0.92±0.86	0.866
After	1.00±0.87	0.83±0.83	0.69±1.03	0.590
Concentration disorders
Before	1.67±0.87	2.08±0.67	2.23±1.01	0.246
After	1.56±0.88	2.00±0.60	1.92±1.04	0.491
Arthralgia or myalgia
Before	1.67±0.87	2.00±0.95	2.23±1.01	0.285
After	1.56±0.53	2.00±0.95	1.92±1.04	0.397
Headache
Before	0.78±0.83	1.75±1.06	1.77±1.17	0.068
After	0.67±0.87	1.42±1.24	1.31±1.11	0.281
Palpitations
Before	1.00±1.00	0.92±1.00	1.08±1.12	0.947
After	0.89±0.78	0.75±0.62	0.69±0.75	0.808
Formication
Before	0.00±0.00	0.58±1.00	0.38±0.87	0.177
After	0.11±0.33	0.33±0.49	0.54±0.78	0.322

Data are mean ± SD. 𝑃 values (SS versus SL versus LL) were obtained by Kruskal-Wallis test. 𝑃 values (before versus after) were obtained by Signed-Wilcoxon test.*𝑃<0.05.