Medicinal Plants for the Treatment of Hypertrophic Scars

Table 6

Summary of antiscarring mechanisms of plant extracts.

Mechanism	Medicinal plants extract
Cell cycle
Increase of G0-G1 phase	Rhubarb
Collagen
Downregulation of collagen l expression	Gelidium amansii
Downregulation of collagen III expression	Gelidium amansii, Scutellaria baicalensis Georgi
Enhancement of collagen synthesis	Calotropis gigantea
Inhibition of collagen synthesis	Carthamus tinctorius
Promotion of collagen I	Onion
MMP
Enhancement of MMP-1	Neonauclea reticulata, Onion
Increase of MMP-3 and MMP-9	Neonauclea reticulata
Elimination of hydroxyl radical	Pistia stratiotes
Decrease of LDH	Oenothera paradoxa
Decrease of ROS	Oenothera paradoxa, Neonauclea reticulata
Increase of ROS and reduction of SOD and GSH-Px	Cigarette Smoke