Evidence-Based Complementary and Alternative Medicine / 2015 / Article / Tab 7

Research Article

The Clinical Efficacy and Safety of the Sahastara Remedy versus Diclofenac in the Treatment of Osteoarthritis of the Knee: A Double-Blind, Randomized, and Controlled Trial

Table 7

Blood pressure, renal functions, and liver functions in safety issue.

DataFollow-upTreatment value
SHTDiclofenac

Blood pressure
 Systolic blood pressure (normal ≤ 140 mm.Hg.)Day 0123.55 (11.42)121.83 (13.03)0.66
Day 14126.77 (10.13)127.00 (14.42)
Day 28123.54 (12.79)128.67 (17.95)

 Diastolic blood pressure (normal ≤ 90 mm.Hg.)Day 082.90 (8.24)80.50 (8.13)0.68
Day 1484.03 (6.38)83.50 (7.08)
Day 2883.55 (7.09)84.67 (6.81)

Renal functions
 Blood urea nitrogen; BUN (mg/dL) (ref. range = 7.0–18.0)Day 013.74 (4.69)15.35 (4.55)0.15
Day 1413.98 (3.87)14.70 (4.67)
Day 2813.54 (3.89)14.96 (3.52)

 Creatinine (mg/dL) (ref. range = 0.7–1.3)Day 00.84 (0.27)0.80 (0.20)0.60
Day 140.82 (0.22)0.79 (0.23)
Day 280.81 (0.24)0.80 (0.20)

Liver functions
 AST (U/L) (ref. range = 15–37)Day 028.00 (19.50)22.33 (10.35)0.45
Day 1425.77 (12.54)30.50 (20.88)
Day 2821.61 (7.05)29.00 (14.93)

 ALT (U/L) (ref. range = 30–65)Day 046.48 (23.94)40.90 (12.92)0.00
Day 1444.13 (23.95)55.70 (36.66)†††
Day 2841.03 (11.45)56.37 (32.33)†††

 ALP (U/L) (ref. range = 50–136)Day 0108.26 (25.95)98.27 (23.26)0.19
Day 14110.13 (46.30)98.23 (21.85)
Day 28113.84 (35.68)106.17 (30.68)††

Statistical analysis: repeated measured ANOVA, Friedman’s test.
Significant difference from day 0 within group (), significant difference from day 0 within group (), and
significant difference from day 0 within group ().

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