The Synergistic Beneficial Effects of Ginkgo Flavonoid and Coriolus versicolor Polysaccharide for Memory Improvements in a Mouse Model of Dementia
The CVP and GF treatment paradigm synergistically improves spatial learning and memory abilities in the MWM in a mouse model of dementia. The ICR mice () were supplied with AlCl3 (0.5 mg/mL in water) and intraperitoneally injected with D-gal (10 mg/mL in physiological saline, 100 mg/kg/d). Fifty-four days later, the mice were tested in the MWM. (a) After two days of visible platform training, the mice were subjected to the hidden platform test, and the escape latency was recorded. Statistical analysis was performed to determine the and values versus the model group unless otherwise specified. (b) In the probe trial on the 6th day, the percent time that the mice spent in the fourth quadrant, which is where the hidden platform was previously placed was recorded. The number of times the mice passed through this quadrant was also recorded. Statistical analysis was performed to determine the and values versus the model group unless otherwise specified. ; ; versus model group. (c) The swim-tracking paths employed by mice in the probe trial were recorded. The small blue circle indicates where the hidden platform was previously placed.
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