| | Included trials (years) | Model details |
| |
Zhao et al. (1992) [15] | Pneumococcus, ID, 0.2 mL, 30 million of bacteria count | | Chen et al. (1994) [16] | LPS 0.4 mg, IP | | Luo et al. (1996) [17] | HSV right cerebrum injection, virus titer: 100 LD50/0.1 mL, 0.02 mL per mouse | | Chen et al. (1997) [18] | LPS 4 mg/kg, IV | | Yang et al. (1998) [19] | NA | | Yang et al. (1998) [20] | LPS 4 mg/kg, IV | | Li et al. (2000) [21] | LPS 5 mg/kg, IV | | Li and Chen (2001) [22] | Scald: 30%, third degree; LPS: 20 mg/kg, 12 h after scald procedure | | Shu et al. (2003) [23] | CLP, using 18-gauge needles | | Chen (2003) [24] | Scald: boiling water for 12 s, 25%, third degree; LPS: 20 mg/kg dissolved in 10 mL NS, 1 mL/h, 12 h after scald procedure | | Yin et al. (2003) [25] | CLP, ligated 2/3 cecum with 1-0 suture, perforated 6 times with 7-gauge needles | | Zhang et al. (2007) [26] | LPS 10 ug/kg, IV | | Wu et al. (2007) [27] | CLP, ligated 1/3 cecum, perforated with 18-gauge needles | | Xing et al. (2009) [28] | CLP, ligated cecum at 1 cm to ileocecal junction, perforated twice with 18-gauge needles | | Chen et al. (2009) [29] | Scald: boiling water for 15 s, 30%, third degree; LPS: 10 mg/kg, q12 h × 2 times, 24 h after scald procedure | | Han et al. (2011) [30] | LPS 6 mg/kg, IP | | Huang et al. (2012) [31] | LPS 15 mg/kg, IP | | Ma et al. (2012) [32] | Scald: boiling water for 15 s, 30%, third degree; LPS: 10 mg/kg, bid × 2 times, 24 h after scald procedure | | Ma et al. (2012) [33] | LPS 10 mg/kg, IP | | Li et al. (2013) [34] | LPS 5 mg/kg/h IV for 90 mins | | Li (2013) [35] | CLP, ligated cecum with number 4 suture at 1.5 cm to ileocecal junction, perforated 3 times with 18-gauge needles at 1 cm to ileocecal junction | | Cui (2013) [36] | CLP, ligated 50% of the cecum, perforated once with 18-gauge needles | | Chen et al. (2013) [37] | LPS 10 mg/kg, IP | | Zhang et al. (2014) [38] | Scald: boiling water for 12 s, 30%, third degree; LPS: 5 mg/kg, 12 h after scald procedure | | Su (2014) [39] | LPS 10 mg/kg, IP | | Liu et al. (2014) [40] | CLP, ligated at ileocecal junction with 4-0 suture, perforated once with 18-gauge needles | | Sun et al. (2014) [41] | CLP, ligated at ileocecal junction, perforated once with 21-gauge needles |
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