Review Article

A Systematic Review of Rhubarb (a Traditional Chinese Medicine) Used for the Treatment of Experimental Sepsis

Table 2

Study quality and risk of bias.

Study(1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)TotalScores
+±?

Zhao et al. (1992) [15]+++300143
Chen et al. (1994) [16]+±±120142
Luo et al. (1996) [17]?+±+211132.5
Chen et al. (1997) [18]+++300143
Yang et al. (1998) [19]+++300143
Yang et al. (1998) [20]+++++500125
Li et al. (2000) [21]++±±220133
Li and Chen (2001) [22]?++±±221123
Shu et al. (2003) [23]?++±211132.5
Chen (2003) [24]/++±±220123
Yin et al. (2003) [25]?+++±311123.5
Zhang et al. (2007) [26]++±+±±330114.5
Wu et al. (2007) [27]+++++500125
Xing et al. (2009) [28]?+++301133
Chen et al. (2009) [29]++±+±±330114.5
Han et al. (2011) [30]++±+++510115.5
Huang et al. (2012) [31]++±++++610106.5
Ma et al. (2012) [32]+++++500125
Ma et al. (2012) [33]++±+±±330114.5
Li et al. (2013) [34]+++++500125
Li (2013) [35]/++±+++510105.5
Cui (2013) [36]/++++400124
Chen et al. (2013) [37]+++±310133.5
Zhang et al. (2014) [38]++±++++610106.5
Su (2014) [39]++±+++510115.5
Liu et al. (2014) [40]++++400134
Sun et al. (2014) [41]++±±220143

Note. (1) Peer-reviewed publication; (2) control of temperature, humidity, and light; (3) randomized allocation; (4) reporting details of randomized allocation method; (5) allocation concealment; (6) blinded model induction; (7) blinded intervention administration; (8) blinded outcome assessment; (9) sample size calculation or explanation; (10) animal welfare regulations compliance statement; (11) being free of selective reporting; (12) potential conflict of interests statement; (13) reporting statistical method; (14) reporting numerical data in Result sections; (15) reporting actual numbers of animal samples of different groups in Result sections; (16) completeness of follow-up; (17) intention-to-treat analysis. +: yes, scores 1 point; : no, scores 0 points; ±: partially yes, scores 0.5 points; ?: unclear, scores 0 points; unpublished doctor’s or master’s thesis; randomized allocation according to body weight; details are unavailable; randomized allocation according to random number table; details are unavailable; completely randomized design; details are unavailable.