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Evidence-Based Complementary and Alternative Medicine
Volume 2015, Article ID 142736, 6 pages
http://dx.doi.org/10.1155/2015/142736
Research Article

Agaricoglycerides Protect against Hepatic Ischemia/Reperfusion Injury by Attenuating Inflammatory Response, Oxidative Stress, and Expression of NF-κB

Hospital & Institute of Hepatobiliary Surgery, Chinese PLA General Hospital, Beijing 100853, China

Received 27 August 2014; Accepted 19 October 2014

Academic Editor: Thomas G. Mitchell

Copyright © 2015 Xiang-qian Zhao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We have investigated the effects of agaricoglycerides (AG) in a mouse model of hepatic I/R injury. I/R triggered increases/changes in markers of liver injury, hepatic oxidative stress, tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and nuclear factor κB (NF-κB). AG significantly reduced the extent of liver inflammation and oxidative stress and also attenuated the NF-κB activation as well as TNF-α and IL-1β production. Our results indicate that AG may represent a novel protective strategy against I/R-induced injury and inflammatory diseases.