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Evidence-Based Complementary and Alternative Medicine
Volume 2015, Article ID 171742, 9 pages
http://dx.doi.org/10.1155/2015/171742
Review Article

Medicinal Plants Qua Glucagon-Like Peptide-1 Secretagogue via Intestinal Nutrient Sensors

College of Korean Medicine, Institute of Korean Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea

Received 25 August 2015; Accepted 24 November 2015

Academic Editor: Juntra Karbwang

Copyright © 2015 Ki-Suk Kim and Hyeung-Jin Jang. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. F. M. Ashcroft and P. Rorsman, “Diabetes mellitus and the β cell: the last ten years,” Cell, vol. 148, no. 6, pp. 1160–1171, 2012. View at Publisher · View at Google Scholar · View at Scopus
  2. A. Patel, ADVANCE Collaborative Group, S. MacMahon et al., “Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial,” The Lancet, vol. 370, no. 9590, pp. 829–840, 2007. View at Google Scholar
  3. American Diabetes Association, “Standards of medical care in diabetes—2009,” Diabetes Care, vol. 32, supplement 1, pp. S13–S61, 2009. View at Google Scholar
  4. P. K. Prabhakar, A. Kumar, and M. Doble, “Combination therapy: a new strategy to manage diabetes and its complications,” Phytomedicine, vol. 21, no. 2, pp. 123–130, 2014. View at Publisher · View at Google Scholar · View at Scopus
  5. J. J. Holst, “The physiology of glucagon-like peptide 1,” Physiological Reviews, vol. 87, no. 4, pp. 1409–1439, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. L. L. Baggio and D. J. Drucker, “Biology of incretins: GLP-1 and GIP,” Gastroenterology, vol. 132, no. 6, pp. 2131–2157, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. H.-C. Fehmann, R. Goke, and B. Goke, “Cell and molecular biology of the incretin hormones glucagon-like peptide-I and glucose-dependent insulin releasing polypeptide,” Endocrine Reviews, vol. 16, no. 3, pp. 390–410, 1995. View at Publisher · View at Google Scholar · View at Scopus
  8. D. J. Drucker, S. I. Sherman, F. S. Gorelick, R. M. Bergenstal, R. S. Sherwin, and J. B. Buse, “Incretin-based therapies for the treatment of type 2 diabetes: evaluation of the risks and benefits,” Diabetes Care, vol. 33, no. 2, pp. 428–433, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Nauck, F. Stockmann, R. Ebert, and W. Creutzfeldt, “Reduced incretin effect in type 2 (non-insulin-dependent) diabetes,” Diabetologia, vol. 29, no. 1, pp. 46–52, 1986. View at Publisher · View at Google Scholar · View at Scopus
  10. J.-L. Faillie, L. Azoulay, V. Patenaude, D. Hillaire-Buys, and S. Suissa, “Incretin based drugs and risk of acute pancreatitis in patients with type 2 diabetes: cohort study,” British Medical Journal, vol. 348, Article ID g2780, 2014. View at Publisher · View at Google Scholar · View at Scopus
  11. J. M. Egan, A. R. Clocquet, and D. Elahi, “The insulinotropic effect of acute exendin-4 administered to humans: comparison of nondiabetic state to type 2 diabetes,” Journal of Clinical Endocrinology and Metabolism, vol. 87, no. 3, pp. 1282–1290, 2002. View at Publisher · View at Google Scholar · View at Scopus
  12. H. Agersø, L. B. Jensen, B. Elbrønd, P. Rolan, and M. Zdravkovic, “The pharmacokinetics, pharmacodynamics, safety and tolerability of NN2211, a new long-acting GLP-1 derivative, in healthy men,” Diabetologia, vol. 45, no. 2, pp. 195–202, 2002. View at Publisher · View at Google Scholar · View at Scopus
  13. J. K. Berg, S. K. Shenouda, C. R. Heilmann, A. L. Gray, and J. H. Holcombe, “Effects of exenatide twice daily versus sitagliptin on 24-h glucose, glucoregulatory and hormonal measures: a randomized, double-blind, crossover study,” Diabetes, Obesity and Metabolism, vol. 13, no. 11, pp. 982–989, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. R. A. DeFronzo, T. Okerson, P. Viswanathan, X. Guan, J. H. Holcombe, and L. MacConell, “Effects of exenatide versus sitagliptin on postprandial glucose, insulin and glucagon secretion, gastric emptying, and caloric intake: a randomized, cross-over study,” Current Medical Research and Opinion, vol. 24, no. 10, pp. 2943–2952, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. G. I. Uwaifo and R. E. Ratner, “Novel pharmacologic agents for type 2 diabetes,” Endocrinology and Metabolism Clinics of North America, vol. 34, no. 1, pp. 155–197, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Bodmer, C. Meier, S. Krähenbühl, S. S. Jick, and C. R. Meier, “Metformin, sulfonylureas, or other antidiabetes drugs and the risk of lactic acidosis or hypoglycemia a nested case-control analysis,” Diabetes Care, vol. 31, no. 11, pp. 2086–2091, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. S. E. Inzucchi, R. M. Bergenstal, J. B. Buse et al., “Management of hyperglycemia in type 2 diabetes, 2015: a patient-centered approach: update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes,” Diabetes Care, vol. 38, no. 1, pp. 140–149, 2015. View at Publisher · View at Google Scholar · View at Scopus
  18. F. A. Van de Laar, P. L. Lucassen, R. P. Akkermans, E. H. Van de Lisdonk, and W. J. De Grauw, “Alpha-glucosidase inhibitors for people with impaired glucose tolerance or impaired fasting blood glucose,” Cochrane Database of Systematic Reviews, no. 4, Article ID CD005061, 2006. View at Google Scholar · View at Scopus
  19. R. M. Lago, P. P. Singh, and R. W. Nesto, “Congestive heart failure and cardiovascular death in patients with prediabetes and type 2 diabetes given thiazolidinediones: a meta-analysis of randomised clinical trials,” The Lancet, vol. 370, no. 9593, pp. 1129–1136, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. A. J. Garber, “Long-acting glucagon-like peptide 1 receptor agonists: a review of their efficacy and tolerability,” Diabetes Care, vol. 34, supplement 2, pp. S279–S284, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. D. Dicker, “DPP-4 inhibitors: impact on glycemic control and cardiovascular risk factors,” Diabetes Care, vol. 34, supplement 2, pp. S276–S278, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. Y. Xiong, L. Shen, K. J. Liu et al., “Antiobesity and antihyperglycemic effects of ginsenoside Rb1 in rats,” Diabetes, vol. 59, no. 10, pp. 2505–2512, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. C. Liu, M. Zhang, M.-Y. Hu et al., “Increased glucagon-like peptide-1 secretion may be involved in antidiabetic effects of ginsenosides,” Journal of Endocrinology, vol. 217, no. 2, pp. 185–196, 2013. View at Publisher · View at Google Scholar · View at Scopus
  24. J.-T. Xie, S. R. Mehendale, X. Li et al., “Anti-diabetic effect of ginsenoside Re in ob/ob mice,” Biochimica et Biophysica Acta, vol. 1740, no. 3, pp. 319–325, 2005. View at Publisher · View at Google Scholar · View at Scopus
  25. M. W. Park, J. Ha, and S. H. Chung, “20(S)-ginsenoside Rg3 enhances glucose-stimulated insulin secretion and activates AMPK,” Biological and Pharmaceutical Bulletin, vol. 31, no. 4, pp. 748–751, 2008. View at Publisher · View at Google Scholar · View at Scopus
  26. K.-S. Kim, N. H. Cha, K.-W. Kim et al., “Transcriptomic analysis of the bitter taste receptor-mediated glucagon-like peptide-1 stimulation effect of quinine,” Biochip Journal, vol. 7, no. 4, pp. 386–392, 2013. View at Publisher · View at Google Scholar · View at Scopus
  27. K.-H. Kim, K.-S. Kim, M. H. Shin et al., “Aqueous extracts of Anemarrhena asphodeloides stimulate glucagon-like pepetide-1 secretion in enteroendocrine NCI-H716 cells,” Biochip Journal, vol. 7, no. 2, pp. 188–193, 2013. View at Publisher · View at Google Scholar · View at Scopus
  28. M.-H. Shin, E.-K. Choi, K.-S. Kim et al., “Hexane fractions of Bupleurum falcatum L. stimulates glucagon-like peptide-1 secretion through Gβγ-mediated pathway,” Evidence-Based Complementary and Alternative Medicine, vol. 2014, Article ID 982165, 8 pages, 2014. View at Publisher · View at Google Scholar
  29. E.-K. Choi, K.-S. Kim, H. J. Yang et al., “Hexane fraction of Citrus aurantium L. stimulates glucagon-like peptide-1 (GLP-1) secretion via membrane depolarization in NCI-H716 cells,” Biochip Journal, vol. 6, no. 1, pp. 41–47, 2012. View at Publisher · View at Google Scholar · View at Scopus
  30. H. W. Suh, K. B. Lee, K. S. Kim et al., “A bitter herbal medicine Gentiana scabra root extract stimulates glucagon-like peptide-1 secretion and regulates blood glucose in db/db mouse,” Journal of Ethnopharmacology, vol. 172, pp. 219–226, 2015. View at Publisher · View at Google Scholar
  31. S. Zhang, Y. Ma, J. Li, J. Ma, B. Yu, and X. Xie, “Molecular matchmaking between the popular weight-loss herb hoodia gordonii and GPR119, a potential drug target for metabolic disorder,” Proceedings of the National Academy of Sciences of the United States of America, vol. 111, no. 40, pp. 14571–14576, 2014. View at Publisher · View at Google Scholar · View at Scopus
  32. K. Kim, M. Park, Y. M. Lee, M. R. Rhyu, and H. Y. Kim, “Ginsenoside metabolite compound K stimulates glucagon-like peptide-1 secretion in NCI-H716 cells via bile acid receptor activation,” Archives of Pharmacal Research, vol. 37, no. 9, pp. 1193–1200, 2014. View at Publisher · View at Google Scholar · View at Scopus
  33. R. L. Young, “Sensing via intestinal sweet taste pathways,” Frontiers in Neuroscience, vol. 5, article 23, 2011. View at Publisher · View at Google Scholar · View at Scopus
  34. R. F. Margolskee, “Molecular mechanisms of bitter and sweet taste transduction,” The Journal of Biological Chemistry, vol. 277, no. 1, pp. 1–4, 2002. View at Publisher · View at Google Scholar · View at Scopus
  35. H. Matsunami, J.-P. Montmayeur, and L. B. Buck, “A family of candidate taste receptors in human and mouse,” Nature, vol. 404, no. 6778, pp. 601–604, 2000. View at Publisher · View at Google Scholar · View at Scopus
  36. M. J. Theodorakis, O. Carlson, S. Michopoulos et al., “Human duodenal enteroendocrine cells: source of both incretin peptides, GLP-1 and GIP,” American Journal of Physiology—Endocrinology and Metabolism, vol. 290, no. 3, pp. E550–E559, 2006. View at Publisher · View at Google Scholar · View at Scopus
  37. T.-I. Jeon, B. Zhu, J. L. Larson, and T. F. Osborne, “SREBP-2 regulates gut peptide secretion through intestinal bitter taste receptor signaling in mice,” The Journal of Clinical Investigation, vol. 118, no. 11, pp. 3693–3700, 2008. View at Publisher · View at Google Scholar · View at Scopus
  38. K.-S. Kim, J. M. Egan, and H.-J. Jang, “Denatonium induces secretion of glucagon-like peptide-1 through activation of bitter taste receptor pathways,” Diabetologia, vol. 57, no. 10, pp. 2117–2125, 2014. View at Publisher · View at Google Scholar · View at Scopus
  39. G. Nelson, M. A. Hoon, J. Chandrashekar, Y. Zhang, N. J. P. Ryba, and C. S. Zuker, “Mammalian sweet taste receptors,” Cell, vol. 106, no. 3, pp. 381–390, 2001. View at Publisher · View at Google Scholar · View at Scopus
  40. F. Reimann, G. Tolhurst, and F. M. Gribble, “G-protein-coupled receptors in intestinal chemosensation,” Cell Metabolism, vol. 15, no. 4, pp. 421–431, 2012. View at Publisher · View at Google Scholar · View at Scopus
  41. S. C. Kinnamon, “Taste receptor signalling—from tongues to lungs,” Acta Physiologica, vol. 204, no. 2, pp. 158–168, 2012. View at Publisher · View at Google Scholar · View at Scopus
  42. K. R. Trubey, S. Culpepper, Y. Maruyama, S. C. Kinnamon, and N. Chaudhari, “Tastants evoke cAMP signal in taste buds that is independent of calcium signaling,” American Journal of Physiology—Cell Physiology, vol. 291, no. 2, pp. C237–C244, 2006. View at Publisher · View at Google Scholar · View at Scopus
  43. H.-J. Jang, Z. Kokrashvili, M. J. Theodorakis et al., “Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 38, pp. 15069–15074, 2007. View at Publisher · View at Google Scholar · View at Scopus
  44. L. Ruix-Avila, S. K. McLaughlin, D. Wildman et al., “Coupling of bitter receptor to phosphodiesterase through transducin in taste receptor cells,” Nature, vol. 376, no. 6535, pp. 80–85, 1995. View at Publisher · View at Google Scholar · View at Scopus
  45. W. Thomsen, J. Frazer, and D. Unett, “Functional assays for screening GPCR targets,” Current Opinion in Biotechnology, vol. 16, no. 6, pp. 655–665, 2005. View at Publisher · View at Google Scholar · View at Scopus
  46. R. F. Margolskee, J. Dyer, Z. Kokrashvili et al., “T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 38, pp. 15075–15080, 2007. View at Publisher · View at Google Scholar · View at Scopus
  47. J. Ma, M. Bellon, J. M. Wishart et al., “Effect of the artificial sweetener, sucralose, on gastric emptying and incretin hormone release in healthy subjects,” The American Journal of Physiology—Gastrointestinal and Liver Physiology, vol. 296, no. 4, pp. G735–G739, 2009. View at Publisher · View at Google Scholar · View at Scopus
  48. R. E. Steinert, F. Frey, A. Topfer, J. Drewe, and C. Beglinger, “Effects of carbohydrate sugars and artificial sweeteners on appetite and the secretion of gastrointestinal satiety peptides,” British Journal of Nutrition, vol. 105, no. 9, pp. 1320–1328, 2011. View at Publisher · View at Google Scholar · View at Scopus
  49. A. C. Gerspach, R. E. Steinert, L. Schönenberger, A. Graber-Maier, and C. Beglinger, “The role of the gut sweet taste receptor in regulating glp-1, PYY, and CCK release in humans,” The American Journal of Physiology—Endocrinology and Metabolism, vol. 301, no. 2, pp. E317–E325, 2011. View at Publisher · View at Google Scholar · View at Scopus
  50. K.-T. Lee, T. W. Jung, H.-J. Lee, S.-G. Kim, Y.-S. Shin, and W.-K. Whang, “The antidiabetic effect of ginsenoside Rb2 via activation of AMPK,” Archives of Pharmacal Research, vol. 34, no. 7, pp. 1201–1208, 2011. View at Publisher · View at Google Scholar · View at Scopus
  51. E. Rozengurt, “Taste receptors in the gastrointestinal tract. I. Bitter taste receptors and α-gustducin in the mammalian gut,” American Journal of Physiology—Gastrointestinal and Liver Physiology, vol. 291, no. 2, pp. G171–G177, 2006. View at Publisher · View at Google Scholar · View at Scopus
  52. M. Behrens and W. Meyerhof, “Gustatory and extragustatory functions of mammalian taste receptors,” Physiology and Behavior, vol. 105, no. 1, pp. 4–13, 2011. View at Publisher · View at Google Scholar · View at Scopus
  53. W. Meyerhof, C. Batram, C. Kuhn et al., “The molecular receptive ranges of human TAS2R bitter taste receptors,” Chemical Senses, vol. 35, no. 2, pp. 157–170, 2010. View at Publisher · View at Google Scholar · View at Scopus
  54. M. Aoki, T. Takao, K. Takao, F. Koike, and N. Suganuma, “Lower expressions of the human bitter taste receptor TAS2R in smokers: reverse transcriptase-polymerase chain reaction analysis,” Tobacco Induced Diseases, vol. 12, no. 1, article 12, 2014. View at Publisher · View at Google Scholar · View at Scopus
  55. D. A. Deshpande, W. C. H. Wang, E. L. McIlmoyle et al., “Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction,” Nature Medicine, vol. 16, no. 11, pp. 1299–1304, 2010. View at Publisher · View at Google Scholar · View at Scopus
  56. A. Dondorp, F. Nosten, K. Stepniewska, N. Day, and N. White, “Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial,” The Lancet, vol. 366, no. 9487, pp. 717–725, 2005. View at Publisher · View at Google Scholar
  57. H. Reyburn, G. Mtove, I. Hendriksen, and L. von Seidlein, “Oral quinine for the treatment of uncomplicated malaria,” British Medical Journal, vol. 339, Article ID b2066, 2009. View at Publisher · View at Google Scholar · View at Scopus
  58. M.-H. Shin, H.-W. Suh, K.-B. Lee et al., “Gentiana scabra extracts stimulate glucagon-like peptide-1 secretion via G protein-coupled receptor pathway,” BioChip Journal, vol. 6, no. 2, pp. 114–119, 2012. View at Publisher · View at Google Scholar · View at Scopus
  59. N. V. DiPatrizio and D. Piomelli, “Intestinal lipid-derived signals that sense dietary fat,” Journal of Clinical Investigation, vol. 125, no. 3, pp. 891–898, 2015. View at Publisher · View at Google Scholar
  60. L. M. Lauffer, R. Iakoubov, and P. L. Brubaker, “GPR119 is essential for oleoylethanolamide-induced glucagon-like peptide-1 secretion from the intestinal enteroendocrine L-cell,” Diabetes, vol. 58, no. 5, pp. 1058–1066, 2009. View at Publisher · View at Google Scholar · View at Scopus
  61. H. E. Parker, A. M. Habib, G. J. Rogers, F. M. Gribble, and F. Reimann, “Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells,” Diabetologia, vol. 52, no. 2, pp. 289–298, 2009. View at Publisher · View at Google Scholar · View at Scopus
  62. S. Odori, K. Hosoda, T. Tomita et al., “GPR119 expression in normal human tissues and islet cell tumors: evidence for its islet-gastrointestinal distribution, expression in pancreatic beta and alpha cells, and involvement in islet function,” Metabolism: Clinical and Experimental, vol. 62, no. 1, pp. 70–78, 2013. View at Publisher · View at Google Scholar · View at Scopus
  63. Z.-L. Chu, C. Carroll, J. Alfonso et al., “A role for intestinal endocrine cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucagon-like Peptide-1 and glucose-dependent insulinotropic Peptide release,” Endocrinology, vol. 149, no. 5, pp. 2038–2047, 2008. View at Publisher · View at Google Scholar · View at Scopus
  64. A. M. Habib, P. Richards, G. J. Rogers, F. Reimann, and F. M. Gribble, “Co-localisation and secretion of glucagon-like peptide 1 and peptide YY from primary cultured human L cells,” Diabetologia, vol. 56, no. 6, pp. 1413–1416, 2013. View at Publisher · View at Google Scholar · View at Scopus
  65. L. B. Katz, J. J. Gambale, P. L. Rothenberg et al., “Effects of JNJ-38431055, a novel GPR119 receptor agonist, in randomized, double-blind, placebo-controlled studies in subjects with type 2 diabetes,” Diabetes, Obesity and Metabolism, vol. 14, no. 8, pp. 709–716, 2012. View at Publisher · View at Google Scholar · View at Scopus
  66. G. Flock, D. Holland, Y. Seino, and D. J. Drucker, “GPR119 regulates murine glucose homeostasis through incretin receptor-dependent and independent mechanisms,” Endocrinology, vol. 152, no. 2, pp. 374–383, 2011. View at Publisher · View at Google Scholar · View at Scopus
  67. M. Zhang, Y. Feng, J. Wang et al., “High-throughput screening for GPR119 modulators identifies a novel compound with anti-diabetic efficacy in db/db mice,” PLoS ONE, vol. 8, no. 5, Article ID e63861, 2013. View at Publisher · View at Google Scholar · View at Scopus
  68. A. F. Hofmann, “The continuing importance of bile acids in liver and intestinal disease,” Archives of Internal Medicine, vol. 159, no. 22, pp. 2647–2658, 1999. View at Publisher · View at Google Scholar · View at Scopus
  69. S. Fiorucci, A. Mencarelli, G. Palladino, and S. Cipriani, “Bile-acid-activated receptors: targeting TGR5 and farnesoid-X-receptor in lipid and glucose disorders,” Trends in Pharmacological Sciences, vol. 30, no. 11, pp. 570–580, 2009. View at Publisher · View at Google Scholar · View at Scopus
  70. Y. Kawamata, R. Fujii, M. Hosoya et al., “A G protein-coupled receptor responsive to bile acids,” The Journal of Biological Chemistry, vol. 278, no. 11, pp. 9435–9440, 2003. View at Publisher · View at Google Scholar · View at Scopus
  71. S. Katsuma, A. Hirasawa, and G. Tsujimoto, “Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1,” Biochemical and Biophysical Research Communications, vol. 329, no. 1, pp. 386–390, 2005. View at Publisher · View at Google Scholar · View at Scopus
  72. S. K. Jo, I. S. Kim, K. S. Yoon, H. H. Yoon, and H. H. Yoo, “Preparation of ginsenosides Rg3, Rk1, and Rg5-selectively enriched ginsengs by a simple steaming process,” European Food Research and Technology, vol. 240, no. 1, pp. 251–256, 2015. View at Publisher · View at Google Scholar · View at Scopus