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Evidence-Based Complementary and Alternative Medicine
Volume 2015, Article ID 182495, 8 pages
http://dx.doi.org/10.1155/2015/182495
Research Article

The Impact of Paeoniflorin on α-Synuclein Degradation Pathway

1Lianyungang First People’s Hospital Postdoctoral Innovative Practice Base, Nanjing Medical University Postdoctoral Research Station, Lianyungang 222002, China
2Department of Neurology, Affiliated Lianyungang Hospital of Xuzhou Medical College, Lianyungang 222002, China
3Department of Emergency, Affiliated Lianyungang Hospital of Xuzhou Medical College, Lianyungang 222002, China

Received 11 August 2015; Revised 8 November 2015; Accepted 11 November 2015

Academic Editor: Giuseppe Esposito

Copyright © 2015 Zenglin Cai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. Vekrellis, M. Xilouri, E. Emmanouilidou, H. J. Rideout, and L. Stefanis, “Pathological roles of alpha-synuclein in neurological disorders,” The Lancet Neurology, vol. 10, no. 11, pp. 1015–1025, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. L. V. Kalia, S. K. Kalia, P. J. McLean, A. M. Lozano, and A. E. Lang, “α-Synuclein oligomers and clinical implications for parkinson disease,” Annals of Neurology, vol. 73, no. 2, pp. 155–169, 2013. View at Publisher · View at Google Scholar · View at Scopus
  3. K. Wang, L. Zhu, X. Zhu et al., “Protective effect of paeoniflorin on Abeta25-35-induced SH-SY5Y cell injury by preventing mitochondrial dysfunction,” Cellular and Molecular Neurobiology, vol. 34, no. 2, pp. 227–234, 2014. View at Publisher · View at Google Scholar · View at Scopus
  4. B. Lin, “Polyphenols and neuroprotection against ischemia and neurodegeneration,” Mini-Reviews in Medicinal Chemistry, vol. 11, no. 14, pp. 1222–1238, 2011. View at Google Scholar · View at Scopus
  5. R.-B. Guo, G.-F. Wang, A.-P. Zhao, J. Gu, X.-L. Sun, and G. Hu, “Paeoniflorin protects against ischemia-induced brain damages in rats via inhibiting MAPKs/NF-κB-mediated inflammatory responses,” PLoS ONE, vol. 7, no. 11, Article ID e49701, 2012. View at Publisher · View at Google Scholar · View at Scopus
  6. X. Sun, Y.-B. Cao, L.-F. Hu et al., “ASICs mediate the modulatory effect by paeoniflorin on alpha-synuclein autophagic degradation,” Brain Research, vol. 1396, pp. 77–87, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. Z.-L. Cai, J.-J. Shi, Y.-P. Yang et al., “MPP+ impairs autophagic clearance of alpha-synuclein by impairing the activity of dynein,” NeuroReport, vol. 20, no. 6, pp. 569–573, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. S. A. Tanik, C. E. Schultheiss, L. A. Volpicelli-Daley, K. R. Brunden, and V. M. Y. Lee, “Lewy body-like α-synuclein aggregates resist degradation and impair macroautophagy,” The Journal of Biological Chemistry, vol. 288, no. 21, pp. 15194–15210, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. L. L. Venda, S. J. Cragg, V. L. Buchman, and R. Wade-Martins, “α-Synuclein and dopamine at the crossroads of Parkinson's disease,” Trends in Neurosciences, vol. 33, no. 12, pp. 559–568, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Jimenez-Sanchez, F. Thomson, E. Zavodszky, and D. C. Rubinsztein, “Autophagy and polyglutamine diseases,” Progress in Neurobiology, vol. 97, no. 2, pp. 67–82, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. L. G. Verhoef, K. Lindsten, M. G. Masucci, and N. P. Dantuma, “Aggregate formation inhibits proteasomal degradation of polyglutamine proteins,” Human Molecular Genetics, vol. 11, pp. 2689–2700, 2002. View at Google Scholar
  12. R. Rott, R. Szargel, V. Shani, S. Bisharat, and S. Engelender, “α-Synuclein ubiquitination and novel therapeutic targets for Parkinson's disease,” CNS & Neurological Disorders—Drug Targets, vol. 13, no. 4, pp. 630–637, 2014. View at Publisher · View at Google Scholar · View at Scopus
  13. H.-Q. Liu, W.-Y. Zhang, X.-T. Luo, Y. Ye, and X.-Z. Zhu, “Paeoniflorin attenuates neuroinflammation and dopaminergic neurodegeneration in the MPTP model of Parkinson's disease by activation of adenosine A1 receptor,” British Journal of Pharmacology, vol. 148, no. 3, pp. 314–325, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. K.-H. Chang, W.-L. Chen, L.-C. Lee et al., “Aqueous extract of paeonia lactiflora and paeoniflorin as aggregation reducers targeting chaperones in cell models of spinocerebellar ataxia 3,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID 471659, 471659 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. B.-Y. Cao, Y.-P. Yang, W.-F. Luo et al., “Paeoniflorin, a potent natural compound, protects PC12 cells from MPP+ and acidic damage via autophagic pathway,” Journal of Ethnopharmacology, vol. 131, no. 1, pp. 122–129, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. R. Scherz-Shouval, H. Weidberg, C. Gonen, S. Wilder, Z. Elazar, and M. Oren, “p53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvation,” Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 43, pp. 18511–18516, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. L. R. Gomes, A. T. Vessoni, and C. F. M. Menck, “Three-dimensional microenvironment confers enhanced sensitivity to doxorubicin by reducing p53-dependent induction of autophagy,” Oncogene, vol. 34, pp. 5329–5340, 2015. View at Publisher · View at Google Scholar · View at Scopus
  18. E. Tasdemir, M. C. Maiuri, L. Galluzzi et al., “Regulation of autophagy by cytoplasmic p53,” Nature Cell Biology, vol. 10, no. 6, pp. 676–687, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. L. Qu, S. Huang, D. Baltzis et al., “Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta,” Genes and Development, vol. 18, no. 3, pp. 261–277, 2004. View at Publisher · View at Google Scholar · View at Scopus
  20. O. Pluquet, L.-K. Qu, D. Baltzis, and A. E. Koromilas, “Endoplasmic reticulum stress accelerates p53 degradation by the cooperative actions of Hdm2 and glycogen synthase kinase 3β,” Molecular and Cellular Biology, vol. 25, no. 21, pp. 9392–9405, 2005. View at Publisher · View at Google Scholar · View at Scopus