Research Article

The Flavonoid Apigenin Ameliorates Cisplatin-Induced Nephrotoxicity through Reduction of p53 Activation and Promotion of PI3K/Akt Pathway in Human Renal Proximal Tubular Epithelial Cells

Figure 1

The effects of apigenin on cell viability in cisplatin-treated HK-2 cells. Cells were incubated for 12 and 24 h with different concentrations of apigenin (a). Cells were pretreated with different concentrations of apigenin for 1 h and then exposed to 40 μM of cisplatin for 12 and 24 h (b). Cell viability was measured by MTT assay. Values are means ± SD, . versus untreated cells.
(a)
(b)