Research Article

Pharmacological and Genotoxic Properties of Polyphenolic Extracts of Cedrela odorata L. and Juglans regia L. Barks in Rodents

Table 3

DNA damage according to the comet assay for the assessment of the genotoxicity of J. regia and C. odorata.

TreatmentsComet class
Total0123

Blood samples (4 h)
Negative control40.5 ± 21.41a77.0 ± 9.38a10.7 ± 4.08a7.2 ± 5.60a5.2 ± 3.54a
CPA (50 mg/kg) 170.2 ± 12.31b5.0 ± 2.28b39.0 ± 7.01b36.8 ± 5.52b19.2 ± 3.12b
J. regia (100 mg/kg)64.0 ± 52.44c60.8 ± 25.4a20.8 ± 6.83bc12.0 ± 11.22c6.4 ± 8.29a
C. odorata (100 mg/kg)31.8 ± 8.93a73.3 ± 6.56a19.8 ± 3.86bc5.5 ± 5.24a0.3 ± 0.18c
J. regia (200 mg/kg)58.7 ± 20.83a65.5 ± 8.07a15.5 ± 5.00a13.8 ± 9.97c5.2 ± 3.60a
C. odorata (200 mg/kg)109.5 ± 30.48b39.2 ± 10.94c25.7 ± 4.67c21.7 ± 3.26d13.5 ± 9.28b
Blood samples (24 h)
Negative control15.0 ± 3.79a87.8 ± 3.37a9.8 ± 3.54a1.8 ± 0.75a0.5 ± 0.83a
CPA (50 mg/kg)96.8 ± 8.93b29.5 ± 5.08b47.3 ± 7.14c20.0 ± 4.56b3.2 ± 1.94b
J. regia (100 mg/kg)9.4 ± 7.53a90.8 ± 7.25a8.6 ± 6.54a0.4 ± 0.89a0a
C. odorata (100 mg/kg)12.3 ± 4.17a88.8 ± 3.43a10.0 ± 2.96a1.2 ± 1.16a0a
J. regia (200 mg/kg)11.8 ± 4.40a89.2 ± 3.86a9.8 ± 3.48a1.0 ± 0.89a0a
C. odorata (200 mg/kg)29.3 ± 15.88c74.7 ± 11.96c21.2 ± 8.95b3.8 ± 0.86c0.2 ± 0.40a

Mean ± standard error. Different letters between groups in each column correspond to significant differences at 4 and 24 hours. , one-way ANOVA; Fisher LSD, comparing the treatments separately at 4 and 24 hours.