Tualang Honey Protects against BPA-Induced Morphological Abnormalities and Disruption of ERα, ERβ, and C3 mRNA and Protein Expressions in the Uterus of Rats

Figure 4

Representative sections of uteri from all experimental groups (H&E, ×40). Normal histological appearance was observed in control group (NC group) ((A), (B), and (C)). Significant disruptive morphological changes were observed in BPA-exposed rats (PC group) ((D), (E), and (F)). The uterus of rat treated with Tualang honey alone (THC group) ((G), (H), and (I)) was comparable to the control group, while concurrent treatment of rats with BPA and Tualang honey (TH group) ((J), (K), and (L)) showed partial prevention of tissues damage from the toxic effect of BPA.

(a) Negative control (vehicle)

(b) Positive control (BPA 10 mg/kg)

(c) Tualang honey control (Tualang honey 200 mg/kg)

(d) Tualang honey (Tualang honey 200 mg/kg + BPA 10 mg/kg)