Randomized Clinical Trial of the Innovative Bilayered Wound Dressing Made of Silk and Gelatin: Safety and Efficacy Tests Using a Split-Thickness Skin Graft Model

Table 4

Blood biochemistry of patients at preoperative and postoperative days of split-thickness skin grafts.

Parameter^a	Preoperative day	Postoperative day (1–3 days)	value^b
	Median ± IQR; (range)	Median ± IQR; (range)
Renal functions
BUN (mg/dL); (normal value: 7–20)	13.00 ± 4.25; (4–26)	10.00 ± 2.50; (4–24)	<0.001
SCr (mg/dL); (normal value: 0.50–1.00)	0.80 ± 0.17; (0.50–1.00)	0.70 ± 0.20; (0.50–1.00)	0.388
Hepatic functions
AST (U/L); (normal value: 5–35)	19.00 ± 10.25; (12–87)	16.00 ± 9.25; (11–60)	0.022
ALT (U/L); (normal value: 0–40)	24.00 ± 10.25; (4–66)	10.50 ± 9.25; (5–46)	<0.001
ALP (U/L); (normal value: 40–120)	80.00 ± 51.00; (46–163)	71.00 ± 53.25; (35–161)	<0.001
Albumin (g/dL); (normal value: 3.0–5.0)	3.60 ± 1.30; (3.0–4.8)	3.20 ± 0.93; (2.2–4.2)	<0.001

BUN: blood urea nitrogen; SCr: serum creatinine; AST: aspartate aminotransferase; ALT: alanine aminotransferase; ALP: alkaline phosphatase.
Calculated by a Wilcoxon signed rank test to compare the difference of each laboratory pre- and postoperative day.