[Retracted] Topical Treatment with Xiaozheng Zhitong Paste (XZP) Alleviates Bone Destruction and Bone Cancer Pain in a Rat Model of Prostate Cancer-Induced Bone Pain by Modulating the RANKL/RANK/OPG Signaling

Figure 6

Quantitative RT-PCR analysis of the relative levels of target gene mRNA transcripts in the tibial bones of individual groups of rats. The relative levels of OPG, RANKL, RANK, IL-8, PTHrP, M-CSF, IGF-1, and TNF-α mRNA transcripts to the control GAPDH in the tibial bones of individual rats at the indicated time points were determined by quantitative RT-PCR. Data are expressed as the means ± SD of individual groups of rats ( per group) from three separated experiments. (a) The levels of OPG mRNA transcripts; (b) the levels of RANKL mRNA transcripts; (c) the levels of RNAK mRNA transcripts; (d) the levels of IL-8 mRNA transcripts; (e) the levels of PTHrP mRNA transcripts; (f) the levels of M-CSF mRNA transcripts; (g) the levels of IGF-1 mRNA transcripts; (h) the levels of TNF-α mRNA transcripts. versus the control group; versus the placebo group.

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