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Evidence-Based Complementary and Alternative Medicine
Volume 2015, Article ID 215892, 14 pages
http://dx.doi.org/10.1155/2015/215892
Research Article

Topical Treatment with Xiaozheng Zhitong Paste (XZP) Alleviates Bone Destruction and Bone Cancer Pain in a Rat Model of Prostate Cancer-Induced Bone Pain by Modulating the RANKL/RANK/OPG Signaling

1Department of Oncology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beixiange 5, Xicheng District, Beijing 100053, China
2Beijing University of Chinese Medicine, Beijing North Third Ring Road No. 11, Chaoyang District, Beijing 100029, China
3Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Nanxiaojie, Dongzhimen District, Beijing 100700, China
4Department of Nephrology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beixiange 5, Xicheng District, Beijing 100053, China

Received 7 September 2014; Revised 19 December 2014; Accepted 20 December 2014

Academic Editor: Yen-Chin Liu

Copyright © 2015 Yanju Bao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. A. C. Sabino and P. W. Mantyh, “Pathophysiology of bone cancer pain,” Journal of Supportive Oncology, vol. 3, no. 1, pp. 15–24, 2005. View at Google Scholar · View at Scopus
  2. S. Mercadante, “Malignant bone pain: pathophysiology and treatment,” Pain, vol. 69, no. 1-2, pp. 1–18, 1997. View at Publisher · View at Google Scholar · View at Scopus
  3. R. E. Coleman, “Clinical features of metastatic bone disease and risk of skeletal morbidity,” Clinical Cancer Research, vol. 12, no. 20, part 2, pp. 6243s–6249s, 2006. View at Publisher · View at Google Scholar
  4. E. Chow, L. Zeng, N. Salvo, K. Dennis, M. Tsao, and S. Lutz, “Update on the systematic review of palliative radiotherapy trials for bone metastases,” Clinical Oncology, vol. 24, no. 2, pp. 112–124, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. R. K. Portenoy, D. Payne, and P. Jacobsen, “Breakthrough pain: characteristics and impact in patients with cancer pain,” Pain, vol. 81, no. 1-2, pp. 129–134, 1999. View at Publisher · View at Google Scholar · View at Scopus
  6. H. J. McQuay, S. L. Collins, D. Carroll, and R. A. Moore, “Radiotherapy for the palliation of painful bone metastases,” Cochrane Database of Systematic Reviews, no. 2, Article ID CD001793, 2000. View at Publisher · View at Google Scholar · View at Scopus
  7. M. D. Michaelson and M. R. Smith, “Bisphosphonates for treatment and prevention of bone metastases,” Journal of Clinical Oncology, vol. 23, no. 32, pp. 8219–8224, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. F. K. L. Chan, “Primer: managing NSAID-induced ulcer complications—balancing gastrointestinal and cardiovascular risks,” Nature Clinical Practice Gastroenterology and Hepatology, vol. 3, no. 10, pp. 563–573, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Lapeyre-Mestre, A. M. Rueda De Castro, M.-P. Bareille et al., “Non-steroidal anti-inflammatory drug-related hepatic damage in France and Spain: analysis from national spontaneous reporting systems,” Fundamental and Clinical Pharmacology, vol. 20, no. 4, pp. 391–395, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. C. Lin, X. Lin, and J. Yang, “An observation on combined use of chemotherapy and traditional Chinese medicine to relieve cancer pain,” Journal of Traditional Chinese Medicine, vol. 16, no. 4, pp. 267–269, 1996. View at Google Scholar · View at Scopus
  11. Y.-J. Bao, B.-J. Hua, W. Hou, H.-S. Lin, X.-B. Zhang, and G.-X. Yang, “Alleviation of cancerous pain by external compress with Xiaozheng Zhitong Paste,” Chinese Journal of Integrative Medicine, vol. 16, no. 4, pp. 309–314, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. N. M. Luger, P. Honore, M. A. C. Sabino et al., “Osteoprotegerin diminishes advanced bone cancer pain,” Cancer Research, vol. 61, no. 10, pp. 4038–4047, 2001. View at Google Scholar · View at Scopus
  13. S. Adami, A. Zivelonghi, V. Braga et al., “Insulin-like growth factor-1 is associated with bone formation markers, PTH and bone mineral density in healthy premenopausal women,” Bone, vol. 46, no. 1, pp. 244–247, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. T. Kubota, H. Z. Elalieh, N. Saless et al., “Insulin-like growth factor-1 receptor in mature osteoblasts is required for periosteal bone formation induced by reloading,” Acta Astronautica, vol. 92, no. 1, pp. 73–78, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. N. Abildgaard, K. Brixen, J. E. Kristensen, E. F. Eriksen, J. L. Nielsen, and L. Heickendorff, “Comparison of five biochemical markers of bone resorption in multiple myeloma: elevated pre-treatment levels of S-ICTP and U-Ntx are predictive for early progression of the bone disease during standard chemotherapy,” British Journal of Haematology, vol. 120, no. 2, pp. 235–242, 2003. View at Publisher · View at Google Scholar · View at Scopus
  16. D. J. Leeming, M. Koizumi, I. Byrjalsen, B. Li, P. Qvist, and L. B. Tankó, “The relative use of eight collagenous and noncollagenous markers for diagnosis of skeletal metastases in breast, prostate, or lung cancer patients,” Cancer Epidemiology Biomarkers and Prevention, vol. 15, no. 1, pp. 32–38, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. A. G. Zafeirakis, G. A. Papatheodorou, and G. S. Limouris, “Clinical and imaging correlations of bone turnover markers in prostate cancer patients with bone only metastases,” Nuclear Medicine Communications, vol. 31, no. 3, pp. 249–253, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. P. Mantyh, “Bone cancer pain: causes, consequences, and therapeutic opportunities,” Pain, vol. 154, supplement 1, pp. S54–S62, 2013. View at Publisher · View at Google Scholar · View at Scopus
  19. T. Yoneda, K. Hata, M. Nakanishi et al., “Involvement of acidic microenvironment in the pathophysiology of cancer-associated bone pain,” Bone, vol. 48, no. 1, pp. 100–105, 2011. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Zimmermann, “Ethical guidelines for investigations of experimental pain in conscious animals,” Pain, vol. 16, no. 2, pp. 109–110, 1983. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. Bao, B. Hua, W. Hou et al., “Involvement of protease-activated receptor 2 in nociceptive behavior in a rat model of bone cancer,” Journal of Molecular Neuroscience, vol. 52, no. 4, pp. 566–576, 2014. View at Publisher · View at Google Scholar · View at Scopus
  22. S. M. Sweitzer, R. W. Colburn, M. Rutkowski, and J. A. DeLeo, “Acute peripheral inflammation induces moderate glial activation and spinal IL-1β expression that correlates with pain behavior in the rat,” Brain Research, vol. 829, no. 1-2, pp. 209–221, 1999. View at Publisher · View at Google Scholar · View at Scopus
  23. F. Lamoureux, M. Baud’huin, L. Rodriguez Calleja et al., “Selective inhibition of BET bromodomain epigenetic signalling interferes with the bone-associated tumour vicious cycle,” Nature Communications, vol. 5, p. 3511, 2014. View at Google Scholar
  24. A. Parsa, N. Ibrahim, B. Hassan, P. van der Stelt, and D. Wismeijer, “Bone quality evaluation at dental implant site using multislice CT, micro-CT, and cone beam CT,” Clinical Oral Implants Research, vol. 26, no. 1, pp. e1–e7, 2015. View at Publisher · View at Google Scholar · View at Scopus
  25. J. Wang, R. Zhang, C. Dong et al., “Topical treatment with Tong-Luo-San-Jie gel alleviates bone cancer pain in rats,” Journal of Ethnopharmacology, vol. 143, no. 3, pp. 905–913, 2012. View at Publisher · View at Google Scholar · View at Scopus
  26. Y. Bao, W. Hou, R. Liu et al., “PAR2-mediated upregulation of BDNF contributes to central sensitization in bone cancer pain,” Molecular Pain, vol. 10, no. 1, article 28, 2014. View at Publisher · View at Google Scholar · View at Scopus
  27. R. E. Coleman, “Metastatic bone disease: clinical features, pathophysiology and treatment strategies,” Cancer Treatment Reviews, vol. 27, no. 3, pp. 165–176, 2001. View at Publisher · View at Google Scholar · View at Scopus
  28. V. DePuy, K. J. Anstrom, L. D. Castel, K. A. Schulman, K. P. Weinfurt, and F. Saad, “Effects of skeletal morbidities on longitudinal patient-reported outcomes and survival in patients with metastatic prostate cancer,” Supportive Care in Cancer, vol. 15, no. 7, pp. 869–876, 2007. View at Publisher · View at Google Scholar · View at Scopus
  29. J. R. Canon, M. Roudier, R. Bryant et al., “Inhibition of RANKL blocks skeletal tumor progression and improves survival in a mouse model of breast cancer bone metastasis,” Clinical & Experimental Metastasis, vol. 25, no. 2, pp. 119–129, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. D. B. Mach, S. D. Rogers, M. C. Sabino et al., “Origins of skeletal pain: sensory and sympathetic innervation of the mouse femur,” Neuroscience, vol. 113, no. 1, pp. 155–166, 2002. View at Publisher · View at Google Scholar · View at Scopus
  31. S. J. Medhurst, K. Walker, M. Bowes et al., “A rat model of bone cancer pain,” Pain, vol. 96, no. 1-2, pp. 129–140, 2002. View at Publisher · View at Google Scholar · View at Scopus
  32. P. W. Wacnik, L. J. Kehl, T. M. Trempe, M. L. Ramnaraine, A. J. Beitz, and G. L. Wilcox, “Tumor implantation in mouse humerus evokes movement-related hyperalgesia exceeding that evoked by intramuscular carrageenan,” Pain, vol. 101, no. 1-2, pp. 175–186, 2003. View at Publisher · View at Google Scholar · View at Scopus
  33. M. El Mouedden and T. F. Meert, “Evaluation of pain-related behavior, bone destruction and effectiveness of fentanyl, sufentanil, and morphine in a murine model of cancer pain,” Pharmacology Biochemistry and Behavior, vol. 82, no. 1, pp. 109–119, 2005. View at Publisher · View at Google Scholar · View at Scopus
  34. D. R. Clohisy and P. W. Mantyh, “Bone cancer pain and the role of RANKL/OPG,” Journal of Musculoskeletal Neuronal Interactions, vol. 4, no. 3, pp. 293–300, 2004. View at Google Scholar · View at Scopus
  35. M. P. Roudier, S. D. Bain, and W. C. Dougall, “Effects of the RANKL inhibitor, osteoprotegerin, on the pain and histopathology of bone cancer in rats,” Clinical and Experimental Metastasis, vol. 23, no. 3-4, pp. 167–175, 2006. View at Publisher · View at Google Scholar · View at Scopus
  36. S. Fili, M. Karalaki, and B. Schaller, “Mechanism of bone metastasis: the role of osteoprotegerin and of the host-tissue microenvironment-related survival factors,” Cancer Letters, vol. 283, no. 1, pp. 10–19, 2009. View at Publisher · View at Google Scholar · View at Scopus
  37. M. C. Bezerra, J. F. Carvalho, A. S. Prokopowitsch, and R. M. R. Pereira, “RANK, RANKL and osteoprotegerin in arthritic bone loss,” Brazilian Journal of Medical and Biological Research, vol. 38, no. 2, pp. 161–170, 2005. View at Publisher · View at Google Scholar · View at Scopus
  38. Y.-D. Bai, F.-S. Yang, K. Xuan, Y.-X. Bai, and B.-L. Wu, “Inhibition of RANK/RANKL signal transduction pathway: a promising approach for osteoporosis treatment,” Medical Hypotheses, vol. 71, no. 2, pp. 256–258, 2008. View at Publisher · View at Google Scholar · View at Scopus
  39. M. El Mouedden and T. F. Meert, “The impact of the opioids fentanyl and morphine on nociception and bone destruction in a murine model of bone cancer pain,” Pharmacology Biochemistry and Behavior, vol. 87, no. 1, pp. 30–40, 2007. View at Publisher · View at Google Scholar · View at Scopus
  40. P. Zwolak, A. Z. Dudek, V. D. Bodempudi et al., “Local irradiation in combination with bevacizumab enhances radiation control of bone destruction and cancer-induced pain in a model of bone metastases,” International Journal of Cancer, vol. 122, no. 3, pp. 681–688, 2008. View at Publisher · View at Google Scholar · View at Scopus
  41. Y. S. Li, J. X. Wang, M. M. Jia, M. Liu, X.-J. Li, and H.-B. Tang, “Dragon's blood inhibits chronic inflammatory and neuropathic pain responses by blocking the synthesis and release of substance P in rats,” Journal of Pharmacological Sciences, vol. 118, no. 1, pp. 43–54, 2012. View at Publisher · View at Google Scholar · View at Scopus
  42. L.-S. Wei, S. Chen, X.-J. Huang, J. Yao, and X.-M. Liu, “Material basis for inhibition of dragon's blood on capsaicin-induced TRPV1 receptor currents in rat dorsal root ganglion neurons,” European Journal of Pharmacology, vol. 702, no. 1–3, pp. 275–284, 2013. View at Publisher · View at Google Scholar · View at Scopus
  43. C. Wang, S. Wang, G. Fan, and H. Zou, “Screening of antinociceptive components in Corydalis yanhusuo W.T. Wang by comprehensive two-dimensional liquid chromatography/tandem mass spectrometry,” Analytical and Bioanalytical Chemistry, vol. 396, no. 5, pp. 1731–1740, 2010. View at Publisher · View at Google Scholar · View at Scopus
  44. C.-S. Yuan, S. R. Mehendale, C.-Z. Wang et al., “Effects of Corydalis yanhusuo and Angelicae dahuricae on cold pressor-induced pain in humans: a controlled trial,” The Journal of Clinical Pharmacology, vol. 44, no. 11, pp. 1323–1327, 2004. View at Publisher · View at Google Scholar · View at Scopus
  45. S. Su, Y. Hua, Y. Wang et al., “Evaluation of the anti-inflammatory and analgesic properties of individual and combined extracts from Commiphora myrrha, and Boswellia carterii,” Journal of Ethnopharmacology, vol. 139, no. 2, pp. 649–656, 2012. View at Publisher · View at Google Scholar · View at Scopus