Research Article

Icariin Prevents Amyloid Beta-Induced Apoptosis via the PI3K/Akt Pathway in PC-12 Cells

Figure 4

Icariin inhibits Aβ25–35-induced cytotoxicity through the activation of PI3K/Akt signaling. After 1 h pretreatment with the PI3K inhibitor LY294002 (50 μM), PC12 cells were treated with 20 μM icariin for 1 h, followed by Aβ25–35 treatment for 24 h. Phosphorylation of Akt was assessed by western blot. Densitometry values represent the mean ± S.D. of triplicate independent experiments. versus untreated control; versus Aβ25–35 treatment; versus icariin treatment.
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