Small Molecules from Nature Targeting G-Protein Coupled Cannabinoid Receptors: Potential Leads for Drug Discovery and Development

Table 4

The cannabinoid receptor affinity, potency, and activity of medicinal plants.

Medicinal plants	CB mediated effect	CB affinity/potency	References
Corydalis yanhusuo	Neuropathic pain	CB1 antagonist	Huang et al. 2010 [119]
Echinacea purpurea	Immunomodulation	CB2 agonist	Chicca et al. 2009 [25]
Linum usitatissimum	Inflammation	CB2 agonist	Styrczewska et al. 2012 [120]
Melilotus suaveolens	Lung injury	CB2 agonist	Liu et al. 2014 [121]
Morinda citrifolia	Immunomodulation	CB1 antagonist/CB2 agonist	Palu et al. 2008 [122]
Nelumbo nucifera	Obesity	CB2 agonist	Velusami et al. 2013 [123]
Olea europaea	Colon cancer	CB1 agonist	Cotrim et al. 2012 [124]
Rubus coreanus	Osteoporosis	CB1 antagonist/CB2 agonist	Lim et al. 2015 [125]
Ruta graveolens	Diabetes	CB2 agonist	Rollinger et al. 2009 [126]