Topical Hypericum perforatum Improves Tissue Regeneration in Full-Thickness Excisional Wounds in Diabetic Rat Model

Table 1

Mean + SD of the numerical density of the fibroblasts (×10³ per mm³), volume densities of the collagen bundles (%) and vessels (%), length density (mm/mm³), and the mean diameter (m) of the vessels in the dermis of the wounded rats treated with Hypericum perforatum 5% and 10% gels (HP5% and HP10%), those treated with gel base, and the untreated group (control).

Groups	Fibroblasts	Collagen	Hair	Vessels
	Numerical density	% Volume density	% Volume density	% Volume density	Length density	Mean diameter
Control	284.5 (32.6)	47.4% (4.9%)	2.6% (1.2%)	3.3% (2.75%)	17.2 (8.1)	11.7 (3.1)
HP5%	454.1 (117.61)	73.1% (9.2%)	2.8% (1.6%)	3.1% (1.4%)	29.3 (6.1)	17.1 (5.5)
HP10%	429.8 (37.6)	74.3% (1.9%)	2.9% (1.2%)	5.1% (2.2%)	32.9 (16.6)	26.6 (9.4)
Gel base	231.1 (11.9)	48.1% (4.7%)	2.4% (1.3%)	4.1% (0.7%)	14.1 (1.4)	11.2 (1.8)

, HP 5% and HP 10% treated groups versus control group and gel base group.