An Integrative Thrombosis Network: Visualization and Topological Analysis

Table 2

Modularity of the thrombosis network and the identification of modular hubs.

Modules	Number of nodes	Modular hubs	Mechanisms
1	31	Thrombin, GPIb-IX-V, vWF, factor Xa	Platelet adhesion signaling and classic coagulation cascade system
2	22	Talin-RIAM complex, GP IIb/IIIa, p-Y419-Src, CSK	Platelet activation and aggregation through GP IIb/IIIa
3	21	Syk, Fyn, GPVI-FcR, Lyn, p-Y348-Syk	Platelet activation through GPVI-FcR and Syk signal
4	19	Thrombin-activated PAR, G-protein Gq, GNB-GNG complex	Accumulation of soluble agonists for platelet recruitment
5	18	Plasmin, CLFM, uPAR, PAI-1	Fibrin formation and dissolution events
6	14	p-PLCG2, p-SLP-76	Signalosome formation for promoting full platelet activation through PLCG2
7	10	Kininogen, kallikrein, C1q bp, prekallikrein	Kallikrein-kinin system
8	6	Src, activated PAR1	Typical platelet activation signal via ERK