Research Article

Anti-Inflammatory Effects of Monoammonium Glycyrrhizinate on Lipopolysaccharide-Induced Acute Lung Injury in Mice through Regulating Nuclear Factor-Kappa B Signaling Pathway

Figure 3

Effect of MAG on histopathological changes in lung tissues in LPS-induced ALI mice (light microscopy, ×200). MAG (3, 10, and 30 mg/kg) was injected intraperitoneally 1 h prior to LPS instillation. Lungs from each group were collected for histological evaluation at 24 h after LPS was given. Representative histological changes of lung obtained from mice of different groups. Control group (a) shows the normal parenchyma and lung airway; LPS group (b) shows tissue injury and neutrophil infiltration in the bronchovascular area (see arrows); LPS + MAG (3, 10, and 30 mg/kg) group (c, d, e) exhibit reduced tissue injury and neutrophil infiltration.
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