Danhong Promotes Angiogenesis in Diabetic Mice after Critical Limb Ischemia by Activation of CSE-H2S-VEGF Axis
Recovery of blood flow in control and diabetic mice monitored by LPDI. Representative evaluations of ischemic (right) and nonischemic (left) hind limbs, immediately after femoral artery ligation and at weeks 0, 2, and 4. Red and blue indicate normal perfusion and marked blood flow reduction, respectively, in ischemic hind limb. Blood flow recovery (ischemic-to-contralateral hind limb perfusion ratio) is impaired in diabetic versus control mice (nondiabetic mice). Data are expressed as mean ± SD. indicates versus control.