Danhong Promotes Angiogenesis in Diabetic Mice after Critical Limb Ischemia by Activation of CSE-H2S-VEGF Axis
Activation by DH of CSE-hydrogen sulfide- (H2S-) VEGF axis in local tissue of diabetic mice. VEGF mRNA (a) and protein expression (b) in control and DH injected mice. H2S was analyzed by HPLC-FLD, and standard dilutions were used to plot the standard curve ( (AUC) = (H2S, μmol/L) + 7640; ) (c). DH (triangles) versus control (circles) significantly increased H2S (d) and CSE (e) levels in femoral vein blood. Data are expressed as mean ± SD. indicates versus control.