Anti-Inflammatory Activity of Triterpenes Isolated from Protium paniculatum Oil-Resins

Table 1

Cell viability of J774 cells treated with 5, 10, and 20 μg/mL of isolated triterpenes for 24, 48, and 72 hours.

	24 hours			48 hours			72 hours
Concentration (µg/mL)	20	10	5	20	10	5	20	10	5
	Mean ± SE	Mean ± SE	Mean ± SE	Mean ± SE	Mean ± SE	Mean ± SE	Mean ± SE	Mean ± SE	Mean ± SE
α,β-Amyrin	57.3 ± 1.9	86.4 ± 0.8	105.8 ± 2.3	36.4 ± 3.1	88,5 ± 2.8	110.0 ± 2.5	37.1 ± 3.5	88.7 ± 1.2	97.2 ± 1.8
Acetylated α,β-amyrin	87.1 ± 0.5	152.9 ± 0.7	124.4 ± 1.9	32.1 ± 2.4	99.5 ± 3.6	125.0 ± 1.7	47.7 ± 1.9	98.0 ± 2.9	103.5 ± 2.7
α,β-Amyrone	119.4 ± 0.5	153.8 ± 1.8	144.0 ± 0.78	81.9 ± 2.9	126.7 ± 0.7	133.5 ± 1.5	65.3 ± 1.7	102.0 ± 0.7	105.2 ± 3.5
Brein/maniladiol	40.6 ± 1.1	82.4 ± 1.9	97.2 ± 3.5	13.3 ± 2.0	47.6 ± 2.9	90.0 ± 1.2	5.4 ± 0.6	23.8 ± 3.1	80.2 ± 1.6
Indomethacin	100.1 ± 3.2	123.6 ± 2.9	117.5 ± 3.7	50.5 ± 2.8	100.8 ± 1.3	105.9 ± 0.8	57.9 ± 1.1	102.3 ± 1.7	103.8 ± 2.9
Doxorubicin	26.0 ± 0.4	27.3 ± 1.2	25.7 ± 2.6	9.3 ± 1.4	10.0 ± 0.1	10.1 ± 0.2	3.8 ± 0.7	3.9 ± 0.07	3.9 ± 0.1
DMSO	70.8 ± 0.7	108.6 ± 0.6	113.3 ± 0.6	38.9 ± 0.2	98.9 ± 2.7	109.5 ± 2.9	33.4 ± 2.3	98.6 ± 1.1	99.0 ± 1.3
Medium	106.1 ± 4.0	100.0 ± 9.7	101.30 ± 1.5	106.7 ± 1.8	101.9 ± 11.0	103.4 ± 2.1	99.9 ± 4.8	98.9 ± 3.4	95.4 ± 4.2

Notes. Data are presented as % mean ± standard error (). SE: standard error; DMSO: dimethyl sulfoxide.