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Evidence-Based Complementary and Alternative Medicine
Volume 2015 (2015), Article ID 294850, 10 pages
http://dx.doi.org/10.1155/2015/294850
Research Article

Intrauterine Growth Restricted Rats Exercised before and during Pregnancy: Maternal and Perinatal Repercussions

1Laboratory of Experimental Research on Gynecology and Obstetrics, Gynecology, Obstetrics and Mastology Graduate Course, Botucatu Medical School, São Paulo State University (Unesp), 18618-970 Botucatu, SP, Brazil
2Institute of Biological and Health Sciences, University Center of Araguaia, 78600-000 Barra do Garças, MT, Mato Grosso Federal University (UFMT), Brazil

Received 2 April 2015; Revised 8 July 2015; Accepted 12 July 2015

Academic Editor: Fabio Firenzuoli

Copyright © 2015 S. B. Corvino et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This study aimed at evaluating the effect of swimming before and during pregnancy on rats born with intrauterine growth restriction (IUGR) and their offspring. For this, nondiabetic and streptozotocin-induced severely diabetic (SD) pregnant rats were mated and generated offspring with appropriate (control, C) and small (IUGR) for pregnancy age, respectively. Following that, C and IUGR groups were further distributed into nonexercised control (C), exercised control (Cex), nonexercised IUGR (IUGR), and exercised IUGR (IUGRex). IUGR rats presented lower mating rate than control rats. Regardless of physical exercise IUGR rats presented decreased body weight from birth to lactation. At 90 days of life, IUGR rats presented glucose intolerance. Maternal organ weights were increased and relative adiposity of IUGRex rats was lower than Cex. IUGR and IUGRex offspring presented reduced body weight than C and Cex, respectively. IUGRex dams presented an increased rate of appropriate for pregnancy age newborns. IUGEex male and female offspring relative brain weight was increased compared with Cex. Therefore, swimming before and during pregnancy prevented glucose intolerance, reduced general adiposity, and increased maternal and offspring organ weight in rats, showing the benefit of physical exercise for IUGR rats.