Cytotoxic Activity and Chemical Composition of the Root Extract from the Mexican Species Linum scabrellum: Mechanism of Action of the Active Compound 6-Methoxypodophyllotoxin
Table 1
IC50 values (μg/mL) of dichloromethane/methanol extract and 6MPTOX isolated from Linum scabrellum.
Extract/compound
Cell lines
PC3
MCF7
HF6
SiHa
HFS-30
CH2Cl2:MeOH extract
1.60 ± 0.07
5.7 × 10−1 ± 0.07
5.7 × 10−1 ± 0.07
1.54 ± 0.07
1.02 ± 0.07
6MPTOX
1.7 × 10−1 ± 0.07
6.6 × 10−2 ± 0.07
7.9 × 10−2 ± 0.07
2.74 ± 0.07
6.0 × 10−2 ± 0.07
PTOX
3 × 10−3 ± 0.07
1 × 10−4 ± 0.07
1.4 × 10−3 ± 0.07
1.23 ± 0.07
1 × 10−4 ± 0.07
Taxol
6.2 × 10−1 ± 0.07
1.3 × 10−1 ± 0.07
2.8 × 10−1 ± 0.07
2.30 ± 0.07
1.2 × 10−1 ± 0.07
PC3: prostate cancer, MCF7: breast cancer, HF6: colon cancer, SiHa: cervical cancer, and HFS-30: fibroblasts.
