Huqi San-Evoked Rat Colonic Anion Secretion through Increasing CFTR Expression

Figure 3

Concentration-response curve for HQS-induced response in the mucosa/submucosa preparations of the rat distal colon. Application of different dosage of HQS (0.1, 1.0, and 5.0 mg/mL) on the responses (a). The scattergram illustrates the effect of basolateral application of different concentrations of HQS on the transepithelial resistance. At the dosage of HQS (1.0 mg/mL), the colonic transepithelial resistance was significantly reduced by 58.33% (, ) (b). Representative traces of basolateral addition of HQS-evoke responses at the concentration of 0.1, 1.0, and 5.0 mg/mL. Arrowheads indicate the time of HQS addition (c). Unpaired -test was used. Values are represented as means ± SEM; , .

(a)

(b)

(c)