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Evidence-Based Complementary and Alternative Medicine
Volume 2015 (2015), Article ID 309261, 14 pages
http://dx.doi.org/10.1155/2015/309261
Review Article

Neuropharmacological Potential of Gastrodia elata Blume and Its Components

1College of Veterinary Medicine and Animal Medical Institute, Chonnam National University, Gwangju 500-757, Republic of Korea
2Cheongju Hamsoa Oriental Clinic, Cheongju 361-814, Republic of Korea
3College of Veterinary Medicine, Jeju National University, Jeju 690-756, Republic of Korea

Received 21 April 2015; Revised 6 September 2015; Accepted 15 September 2015

Academic Editor: Thierry Hennebelle

Copyright © 2015 Jung-Hee Jang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Research has been conducted in various fields in an attempt to develop new therapeutic agents for incurable neurodegenerative diseases. Gastrodia elata Blume (GE), a traditional herbal medicine, has been used in neurological disorders as an anticonvulsant, analgesic, and sedative medication. Several neurodegenerative models are characterized by oxidative stress and inflammation in the brain, which lead to cell death via multiple extracellular and intracellular signaling pathways. The blockade of certain signaling cascades may represent a compensatory therapy for injured brain tissue. Antioxidative and anti-inflammatory compounds isolated from natural resources have been investigated, as have various synthetic chemicals. Specifically, GE rhizome extract and its components have been shown to protect neuronal cells and recover brain function in various preclinical brain injury models by inhibiting oxidative stress and inflammatory responses. The present review discusses the neuroprotective potential of GE and its components and the related mechanisms; we also provide possible preventive and therapeutic strategies for neurodegenerative disorders using herbal resources.