Neuroprotective Effect of Radix Trichosanthis Saponins on Subarachnoid Hemorrhage

Figure 3

RT saponins increased SOD activity after SAH at 24 h. (a) After pretreatment with RT saponins (2 mg/kg/d and 3 mg/kg/d), cortexes were collected after 24 h of SAH. Significantly decreased Cu/Zn-SOD level was observed at 3 mg/kg/d RT saponins group, whereas dramatically increased Mn-SOD activities were detected after RT saponins treatment with 2 mg/kg/d and 3 mg/kg/d dosage; (b) after SAH, serum was used to detect T-SOD, Cu/Zn-SOD, and Mn-SOD activities. Contrary to decreased T-SOD and Cu/Zn-SOD levels after SAH, T-SOD and Cu/Zn-SOD levels were significantly increased only after 2 mg/kg/d RT pretreatment, whereas 3 mg/kg/d RT saponins significantly increased Mn-SOD acitivity. All the experiments were performed as described in Materials and Methods. Data are expressed as the mean ± SD of three independent experiments. versus sham; versus SAH; versus SAH.

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