Pharmacogenomics and Herb-Drug Interactions: Merge of Future and Tradition
Table 2
Transporter gene polymorphisms and HDIs.
Herbal medicines
Drugs
Genes
Polymorphisms
Pharmacogenomics in HDIs effects
References
Apple juice
Fexofenadine
SLCO2B1
c.1457C>T
Administering with apple juice decreased the fexofenadine AUC compared with control (1342 ± 519 versus 284 ± 79.2 ng⋅h/mL). The apple juice induced decrease in fexofenadine AUC was significantly lower in subjects carrying the c.[1457C>T] allele.
After baicalin treatment, the and of rosuvastatin were decreased according to OATP1B1 haplotype 1b/1b (47.0 ± 11.0% and 41.9 ± 7.19%), 1b/15 (21.0 ± 20.6% and 23.9 ± 8.66%), and 15/15 (9.20 ± 11.6% and 1.76 ± 4.89%), respectively.
When tested against the S, XS11, LG, LA, XL17, and XL18 alleles, 100 mM berberine increased 5-HTT promoter activities by 67%, 128.7%, 106.9%, 100.4%, 26.2%, and 82%, 2 mM evodiamine increased 5-HTT promoter activities by 216.7%, 81.6%, 305.6%, 181.5%, 175.3%, and 102.2%, respectively.
When coingested with orange juice, the of montelukast detected with a significant reduction in G/G homozygotes compared with control (2010 ± 650 versus 2560 ± 900 ng⋅h/mL).
Digoxin effluxes were significantly decreased in MDR1 gene variants of 2677T/893Ser with the treatment of P. cocos and of 2677G/893Ala and 2677T/893Ser with the treatment of D. dasycarpus.
of fexofenadine in ABCB1 3435T mutation allele carriers was longer compared to ABCB1 3435CC carriers (4.43 ± 1.44 h versus 2.54 ± 0.21 h), while RA extract pretreatment lengthened in ABCB1 3435CC carriers and abolished such genotype-related difference.
The grapefruit juice-induced inhibition of its transport/formation (mean fold-decrease ± SD, 1.5 ± 0.8, 1.1 ± 0.9, and 0.9 ± 0.4) for CC, CT, and TT carriers, respectively.
Grapefruit juice increased the of pitavastatin acid by 14%; SLCO1B1 1b/1b haplotype (388GG-521TT) had 47% and 44% higher pitavastatin acid exposure than SLCO1B1 1a carriers (388AA/AG-521TT).
Subjects harbouring the ABCB1 haplotype comprising 1236C>T, 2677G>T/A, and 3435C>T polymorphisms had lower intestinal MDR1 mRNA levels and showed an attenuated inductive response to St. John’s wort as assessed by talinolol disposition.
SLCO1B1 c.521TT genotype subjects presented a trend for lower mean concentrations and AUCs of insulin than c.521TC and CC genotypes subjects, but this trend did not reach statistical significance.
