Rhein Elicits In Vitro Cytotoxicity in Primary Human Liver HL-7702 Cells by Inducing Apoptosis through Mitochondria-Mediated Pathway

Table 2

Conversion of animal doses to HED based on BSA.

Species	Weight (kg)	BSA (m^2)	factor
Human
Adult	60	1.6	37
Child	20	0.8	25
Baboon	12	0.6	20
Dog	10	0.5	20
Monkey	3	0.24	12
Rabbit	1.8	0.15	12
Guinea pig	0.4	0.05	8
Rat	0.15	0.025	6
Hamster	0.08	0.02	5
Mouse	0.02	0.007	3

Values based on data from FDA Draft Guidelines [84].
HED: human equivalent dose, BSA: body surface area.
To convert dose in mg/kg to dose in mg/m², multiply by   value.