Toxicopathological Evaluation of Hydroethanol Extract of Dianthus basuticus in Wistar Rats

Table 3

Liver and kidney function parameters of male Wistar rats administered with hydroethanol extract of Dianthus basuticus.

Parameters	Dose (mg/kg body weight/day)
	Control	200	400	800
Total bilirubin (mol/L)	5.00 ± 1.00	5.67 ± 2.08	4.00 ± 1.73	7.00 ± 1.41
Conjugated bilirubin (mol/L)	2.33 ± 0.58	3.00 ± 0.00	1.67 ± 0.58	3.50 ± 0.71
Total protein (g/L)	62.33 ± 4.16	64.00 ± 4.36	65.67 ± 0.68	65.33 ± 0.58
Albumin (g/L)	33.00 ± 0.50	33.33 ± 0.45	33.33 ± 0.06	35.00 ± 0.28
Globulin (g/L)	29.33 ± 4.16	30.67 ± 3.21	32.33 ± 0.57	34.00 ± 0.72
Alkaline phosphatase (U/L)	277.67 ± 26.91	287.67 ± 21.72	314.00 ± 20.48^***	276.00 ± 4.24
-Glutamyl transferase (U/L)	3.00 ± 3.46	3.00 ± 2.00	1.33 ± 0.57	4.00 ± 1.41
Aspartate aminotransferase (U/L)	179.00 ± 23.07	168.33 ± 4.04	145.67 ± 13.57^***	187.50 ± 6.36
Alanine aminotransferase (U/L)	81.67 ± 7.09	75.33 ± 6.43	75.00 ± 5.29	84.00 ± 5.66
Sodium (mmol/L)	144.00 ± 1.00	145.67 ± 1.53	145.67 ± 1.53	142.50 ± 2.12
Potassium (mmol/L)	5.10 ± 0.20	4.93 ± 0.45	4.53 ± 0.31	5.40 ± 0.14
Calcium (mmol/L)	2.48 ± 0.01	2.49 ± 0.06	2.54 ± 0.09	2.46 ± 0.01
Creatinine (mmol/L)	43.00 ± 2.00	36.00 ± 1.53	46.00 ± 5.00	43.00 ± 5.66
Chloride (mmol/L)	103.00 ± 1.00	105.67 ± 1.15	104.33 ± 1.52	105.50 ± 2.12
Urea (mmol/L)	5.90 ± 0.44	7.20 ± 1.08	5.83 ± 0.61	5.60 ± 0.71
Uric acid (mmol/L)	0.09 ± 0.00	0.07 ± 0.01	0.07 ± 0.01	0.10 ± 0.00

Values are presented as mean ± SEM ().
^***Statistically different from the control at .