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Evidence-Based Complementary and Alternative Medicine
Volume 2015, Article ID 350410, 9 pages
http://dx.doi.org/10.1155/2015/350410
Research Article

Cytotoxic and Antimigratory Activities of Phenolic Compounds from Dendrobium brymerianum

1Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
2Faculty of Pharmacy, Rangsit University, Pathum Thani 12000, Thailand
3Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
4Cell-Based Drug and Health Product Development Research Unit, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand

Received 16 October 2014; Revised 18 December 2014; Accepted 22 December 2014

Academic Editor: Maryna Van de Venter

Copyright © 2015 Pornprom Klongkumnuankarn et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Chromatographic separation of a methanol extract prepared from the whole plant of Dendrobium brymerianum led to the isolation of eight phenolic compounds. Among the isolated compounds (18), moscatilin (1), gigantol (3), lusianthridin (4), and dendroflorin (6) showed appreciable cytotoxicity against human lung cancer cell lines with IC50 values of 196.7, 23.4, 65.0, and 125.8 μg/mL, respectively, and exhibited antimigratory property at nontoxic concentrations. This study is the first report on the biological activities of this plant.