Naringin Attenuates Autophagic Stress and Neuroinflammation in Kainic Acid-Treated Hippocampus In Vivo
Protective effect of naringin against excitotoxic neuronal death in the KA-treated hippocampus. Naringin was intraperitoneally injected for 7 days, starting 1 day before KA treatment. Representative pictures of immunoperoxidase staining for NeuN are performed at 1 week after KA treatment (a). Both contralateral controls and naringin alone show intact neurons in the hippocampal CA1 region. Seven days after KA treatment, severe neuronal cell death is distinctly found in the hippocampal CA1 area; however, treatment with naringin reduces KA-induced excitotoxic cell death in the CA1 pyramidal neurons. Scale bar: 500 μm and 100 μm, respectively. The quantitative analysis shows neuroprotective effect of naringin against KA-induced excitotoxicity in the hippocampus (b). and , significantly different from contralateral controls and KA alone, respectively (one-way ANOVA and Tukey post hoc test, for each group). CON: contralateral controls side; EXP: experimental side; KA: KA-treated hippocampus; NAR(80): 80 mg/kg naringin-treated hippocampus; NAR(80)+KA: 80 mg/kg naringin with KA-treated hippocampus.
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