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Evidence-Based Complementary and Alternative Medicine
Volume 2015, Article ID 361607, 9 pages
http://dx.doi.org/10.1155/2015/361607
Research Article

Expression of Caspase-1 Gene Transcript Variant mRNA in Peripheral Blood Mononuclear Cells of Patients with Primary Gout in Different TCM Syndromes

1School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China
2Institute of Rheumatology and Immunology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China
3Nephrology Department, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China

Received 3 January 2015; Revised 15 March 2015; Accepted 16 March 2015

Academic Editor: Klaus Heese

Copyright © 2015 Wan-Tai Dang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. Richette and T. Bardin, “Gout,” The Lancet, vol. 375, no. 9711, pp. 318–328, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. Z. Miao, C. Li, Y. Chen et al., “Dietary and lifestyle changes associated with high prevalence of hyperuricemia and gout in the Shandong coastal cities of Eastern China,” Journal of Rheumatology, vol. 35, no. 9, pp. 1859–1864, 2008. View at Google Scholar · View at Scopus
  3. Y. Shi, J. E. Evans, and K. L. Rock, “Molecular identification of a danger signal that alerts the immune system to dying cells,” Nature, vol. 425, no. 6957, pp. 516–521, 2003. View at Publisher · View at Google Scholar · View at Scopus
  4. R. R. Schumann, C. Belka, D. Reuter et al., “Lipopolysaccharide activates caspase-1 (interleukin-1-converting enzyme) in cultured monocytic and endothelial cells,” Blood, vol. 91, no. 2, pp. 577–584, 1998. View at Google Scholar · View at Scopus
  5. H. Luksch, M. J. Romanowski, O. Chara et al., “Naturally occurring genetic variants of human caspase-1 differ considerably in structure and the ability to activate interleukin-1β,” Human Mutation, vol. 34, no. 1, pp. 122–131, 2013. View at Publisher · View at Google Scholar · View at Scopus
  6. N. Busso and H.-K. Ea, “The mechanisms of inflammation in gout and pseudogout (CPP-induced arthritis),” Reumatismo, vol. 63, no. 4, pp. 230–237, 2012. View at Google Scholar · View at Scopus
  7. W. T. Dang, J. G. Zhou, W. G. Xie et al., “Expression of caspase-1 gene transcript variant mRNA in peripheral blood monocytes of patients with primary gout,” Chinese Journal of Rheumatology, vol. 18, no. 6, p. 400, 2014. View at Google Scholar
  8. S. L. Wallace, H. Robinson, A. T. Masi, J. L. Decker, D. J. McCarty, and T. F. Yü, “Preliminary criteria for the classification of the acute arthritis of primary gout,” Arthritis and Rheumatism, vol. 20, no. 3, pp. 895–900, 1977. View at Publisher · View at Google Scholar · View at Scopus
  9. W. T. Dang, J. G. Zhou, W. G. Xie et al., “Expression of NLRP3 gene transcript variant mRNA in the peripheral blood mononuclear cells of patients with primary gout,” Chinese Journal of Rheumatology (China), vol. 18, no. 2, pp. 76–81, 2014. View at Google Scholar
  10. W. T. Dang, J. G. Zhou, W. G. Xie et al., “Mechanism of NLRP3 inflammasome in inflammatory response with gouty arthritis,” Chinese Journal of Immunology, vol. 30, no. 3, pp. 373–377, 2014. View at Google Scholar
  11. State Bureau of Technical Supervision, The Type of Part, Clinical Diagnosis and Treatment of Traditional Chinese Medicine Terminology, Standards Press of China, Beijing, China, 1997.
  12. X. Y. Zheng, Guiding Principle of Clinical Research on New Drugs of Traditional Chinese Medicine, China Medical Science and Technology Press, Beijing, China, 1995.
  13. W. T. Dang, J. G. Zhou, W. G. Xie et al., “Comparative analysis of clinical indicators of gout patients of different syndrome types and its significance,” Chinese Journal of Integrated Traditional and Western Medicine, vol. 33, no. 10, pp. 1323–1327, 2013. View at Google Scholar
  14. Q. Zeng, R. Chen, J. Darmawan et al., “Rheumatic diseases in China,” Arthritis Research & Therapy, vol. 10, no. 1, p. R17, 2008. View at Publisher · View at Google Scholar
  15. R. M. Pope and J. Tschopp, “The role of interleukin-1 and the inflammasome in gout: implications for therapy,” Arthritis & Rheumatism, vol. 56, no. 10, pp. 3183–3188, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. S. R. Kingsbury, P. G. Conaghan, and M. F. McDermott, “The role of the NLRP3 inflammasome in gout,” Journal of Inflammation Research, vol. 4, no. 1, pp. 39–49, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. E. T. Wang, R. Sandberg, S. Luo et al., “Alternative isoform regulation in human tissue transcriptomes,” Nature, vol. 456, no. 7221, pp. 470–476, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. M. J. Moore, Q. Wang, C. J. Kennedy, and P. A. Silver, “An alternative splicing network links cell-cycle control to apoptosis,” Cell, vol. 142, no. 4, pp. 625–636, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. Y. Barash, J. A. Calarco, W. Gao et al., “Deciphering the splicing code,” Nature, vol. 465, no. 7294, pp. 53–59, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. E. S. Alnemri, T. Fernandes-Alnemri, and G. Litwack, “Cloning and expression of four novel isoforms of human interleukin-1β converting enzyme with different apoptotic activities,” The Journal of Biological Chemistry, vol. 270, no. 9, pp. 4312–4317, 1995. View at Publisher · View at Google Scholar · View at Scopus
  21. Q. Feng, P. Li, P. C. K. Leung, and N. Auersperg, “Caspase-1ζ, a new splice variant of the caspase-1 gene,” Genomics, vol. 84, no. 3, pp. 587–591, 2004. View at Publisher · View at Google Scholar · View at Scopus
  22. C.-N. Son, S.-Y. Bang, J. H. Kim, C.-B. Choi, T.-H. Kim, and J.-B. Jun, “Caspase-1 level in synovial fluid is high in patients with spondyloarthropathy but not in patients with gout,” Journal of Korean Medical Science, vol. 28, no. 9, pp. 1289–1292, 2013. View at Publisher · View at Google Scholar · View at Scopus
  23. R. C. Coll, A. A. Robertson, J. J. Chae et al., “A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases,” Nature Medicine, vol. 21, no. 3, pp. 248–255, 2015. View at Google Scholar